EnglishOBJECTIVE: To identify the time point of the greatest degree of improvement in daily living activities, pain and depression in patients with osteoarthritis (OA) of the knee during 6 months of treatment with NSAIDs, in order to define compliance and drop-out rate.METHODS: 107 patients were recruited into a multicentre, prospective, randomized, controlled trial comparing two treatments, piroxicam-beta-cyclodextrin (PBCD) and slow release diclofenac (DCL).RESULTS: The greatest improvement in quality of life occurred in both groups after 3 months, with a slight further gain observed by the end of treatment. The Stanford Health Assessment Questionnaire score improved (p < 0.05 vs baseline) at 3 and 6 months with PBCD and at 6 months with DCL. The Arthritis Impact Measurement Scale score improved (p < 0.05 vs baseline) after 6 months in both groups. Significant (p < 0.05 vs baseline) improvement in other psychological and pain scores were recorded in both groups after 3 and 6 months. Compliance with treatment at 3 months was 73% for PBCD and 72% for DCL, and was 60% in both groups at 6 months.CONCLUSIONS: The results of this study indicate that the optimal length of time for an NSAID trial in OA patients is 3 months, when assessment of daily living activities is considered as the main outcome criterion.
Quality of life assessment during six months of NSAID treatment [Gonarthrosis and Quality of Life (GOAL) Study] / LA MONTAGNA, G; Tirri, G; Cacace, E; Perpignano, G; Covelli, M; Pipitone, V; D'Agostino, P; Magaro, M; Ferraccioli, G; Mascia, Maria Teresa; Manzini, E; Minari, C; Barreca, C; Marcolongo, R; Paresce, E; Colombo, B.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 16(1)(1998), pp. 49-54.
| Data di pubblicazione: | 1998 | |
| Titolo: | Quality of life assessment during six months of NSAID treatment [Gonarthrosis and Quality of Life (GOAL) Study] | |
| Autore/i: | LA MONTAGNA, G; Tirri, G; Cacace, E; Perpignano, G; Covelli, M; Pipitone, V; D'Agostino, P; Magaro, M; Ferraccioli, G; Mascia, Maria Teresa; Manzini, E; Minari, C; Barreca, C; Marcolongo, R; Paresce, E; Colombo, B. | |
| Autore/i UNIMORE: | ||
| Rivista: | ||
| Volume: | 16(1) | |
| Pagina iniziale: | 49 | |
| Pagina finale: | 54 | |
| Codice identificativo ISI: | WOS:000072462100009 | |
| Codice identificativo Scopus: | 2-s2.0-0031892112 | |
| Codice identificativo Pubmed: | 9543561 | |
| Citazione: | Quality of life assessment during six months of NSAID treatment [Gonarthrosis and Quality of Life (GOAL) Study] / LA MONTAGNA, G; Tirri, G; Cacace, E; Perpignano, G; Covelli, M; Pipitone, V; D'Agostino, P; Magaro, M; Ferraccioli, G; Mascia, Maria Teresa; Manzini, E; Minari, C; Barreca, C; Marcolongo, R; Paresce, E; Colombo, B.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 16(1)(1998), pp. 49-54. | |
| Tipologia | Articolo su rivista |
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