Oral administration of antigen is knon to be appropriate for some vaccine purporses as well as oral tolerance induction. In the present study oral administration of beta lactoglobulin loaded PLGA microspheres induced tolerance was evaluated. A single feeding of five micrograms of encapsulated protein tolerised Balb/c mice to subsequent BLG parenteral challenge, suppressing the specific humoral, intestinal and cellular responses.
Oral tolerance elicited in mice by b-lactoglobulin entrapped in biodegradable microspheres / S., Pecquet; Leo, Eliana Grazia; R., Fritsche; A., Pfeifer; P., Couvreur; E., Fattal. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 18:13(2000), pp. 1196-1202. [10.1016/S0264-410X(99)00384-9]
Oral tolerance elicited in mice by b-lactoglobulin entrapped in biodegradable microspheres.
LEO, Eliana Grazia;
2000
Abstract
Oral administration of antigen is knon to be appropriate for some vaccine purporses as well as oral tolerance induction. In the present study oral administration of beta lactoglobulin loaded PLGA microspheres induced tolerance was evaluated. A single feeding of five micrograms of encapsulated protein tolerised Balb/c mice to subsequent BLG parenteral challenge, suppressing the specific humoral, intestinal and cellular responses.
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