Urethane-anesthetized rats were bled to otherwise irreversible haemorrhagic shock (mean arterial pressure = 18-25 mmHg) and then i.v. treated with ACTH-(1-24) (160 micrograms/kg) or saline. In comparison with sham-operated, non-shocked controls, bled rats showed a significant reduction in Bmax for [3H]Dihydroalprenolol and [3H]Dihydroergocryptine in heart ventricles, and for [3H]Yohimbine in spleen capsule. Neither the Kd of heart and spleen adrenoceptors nor the Bmax or Kd of brain adrenoceptors were affected. Treatment with ACTH-(1-24) restored to normal the Bmax for [3H]Dihydroalprenolol in heart ventricles, and for [3H]Yohimbine in the spleen capsule. These data indicate that the anti-shock effect of ACTH-(1-24) in bled rats is associated with a restoration of heart and spleen responsiveness to adrenergic stimuli.
Influence of the intravenous administration of ACTH-(1-24) on the characteristics of brain, heart and spleen adrenoceptors of haemorrhage-shocked rats / Sandrini, Maurizio; Guarini, Salvatore; Bertolini, Alfio. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 20:(1988), pp. 739-749.
Influence of the intravenous administration of ACTH-(1-24) on the characteristics of brain, heart and spleen adrenoceptors of haemorrhage-shocked rats
SANDRINI, Maurizio;GUARINI, Salvatore;BERTOLINI, Alfio
1988
Abstract
Urethane-anesthetized rats were bled to otherwise irreversible haemorrhagic shock (mean arterial pressure = 18-25 mmHg) and then i.v. treated with ACTH-(1-24) (160 micrograms/kg) or saline. In comparison with sham-operated, non-shocked controls, bled rats showed a significant reduction in Bmax for [3H]Dihydroalprenolol and [3H]Dihydroergocryptine in heart ventricles, and for [3H]Yohimbine in spleen capsule. Neither the Kd of heart and spleen adrenoceptors nor the Bmax or Kd of brain adrenoceptors were affected. Treatment with ACTH-(1-24) restored to normal the Bmax for [3H]Dihydroalprenolol in heart ventricles, and for [3H]Yohimbine in the spleen capsule. These data indicate that the anti-shock effect of ACTH-(1-24) in bled rats is associated with a restoration of heart and spleen responsiveness to adrenergic stimuli.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
