Urethane-anesthetized rats were bled to otherwise irreversible haemorrhagic shock (mean arterial pressure = 18-25 mmHg) and then i.v. treated with ACTH-(1-24) (160 micrograms/kg) or saline. In comparison with sham-operated, non-shocked controls, bled rats showed a significant reduction in Bmax for [3H]Dihydroalprenolol and [3H]Dihydroergocryptine in heart ventricles, and for [3H]Yohimbine in spleen capsule. Neither the Kd of heart and spleen adrenoceptors nor the Bmax or Kd of brain adrenoceptors were affected. Treatment with ACTH-(1-24) restored to normal the Bmax for [3H]Dihydroalprenolol in heart ventricles, and for [3H]Yohimbine in the spleen capsule. These data indicate that the anti-shock effect of ACTH-(1-24) in bled rats is associated with a restoration of heart and spleen responsiveness to adrenergic stimuli.

Influence of the intravenous administration of ACTH-(1-24) on the characteristics of brain, heart and spleen adrenoceptors of haemorrhage-shocked rats / Sandrini, Maurizio; Guarini, Salvatore; Bertolini, Alfio. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 20:(1988), pp. 739-749.

Influence of the intravenous administration of ACTH-(1-24) on the characteristics of brain, heart and spleen adrenoceptors of haemorrhage-shocked rats

SANDRINI, Maurizio;GUARINI, Salvatore;BERTOLINI, Alfio
1988

Abstract

Urethane-anesthetized rats were bled to otherwise irreversible haemorrhagic shock (mean arterial pressure = 18-25 mmHg) and then i.v. treated with ACTH-(1-24) (160 micrograms/kg) or saline. In comparison with sham-operated, non-shocked controls, bled rats showed a significant reduction in Bmax for [3H]Dihydroalprenolol and [3H]Dihydroergocryptine in heart ventricles, and for [3H]Yohimbine in spleen capsule. Neither the Kd of heart and spleen adrenoceptors nor the Bmax or Kd of brain adrenoceptors were affected. Treatment with ACTH-(1-24) restored to normal the Bmax for [3H]Dihydroalprenolol in heart ventricles, and for [3H]Yohimbine in the spleen capsule. These data indicate that the anti-shock effect of ACTH-(1-24) in bled rats is associated with a restoration of heart and spleen responsiveness to adrenergic stimuli.
20
739
749
Influence of the intravenous administration of ACTH-(1-24) on the characteristics of brain, heart and spleen adrenoceptors of haemorrhage-shocked rats / Sandrini, Maurizio; Guarini, Salvatore; Bertolini, Alfio. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 20:(1988), pp. 739-749.
Sandrini, Maurizio; Guarini, Salvatore; Bertolini, Alfio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/453456
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