The putative selective dopamine (DA) D3 receptor agonist, 7-OH-DPAT (25-4000 micrograms kg-1), enhanced stretching-yawning and penile erection in male rats, besides respectively increasing and decreasing sedation at low (25-200 micrograms kg-1) and high (1600 and 4000 micrograms kg-1) doses and inducing stereotypy from 800 micrograms kg-1 upwards. The DA D2 antagonist, (-) eticlopride (10 and 20 micrograms kg-1), antagonized stretching-yawning and penile erection induced by a low dose of 7-OH-DPAT (50 micrograms kg-1) but not those produced by high doses (1600 and 4000 micrograms kg-1), when stereotyped behaviour, on the other hand, was potently inhibited. Comparative experiments performed with the DA agonist SND 919 gave similar results.

BEHAVIOURAL EFFECTS OF THE DOPAMINE D3 RECEPTOR AGONIST, 7-OH-DPAT IN RATS / Ferrari, Francesca; Giuliani, Daniela. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 32:(1995), pp. 63-67.

BEHAVIOURAL EFFECTS OF THE DOPAMINE D3 RECEPTOR AGONIST, 7-OH-DPAT IN RATS.

FERRARI, Francesca;GIULIANI, Daniela
1995

Abstract

The putative selective dopamine (DA) D3 receptor agonist, 7-OH-DPAT (25-4000 micrograms kg-1), enhanced stretching-yawning and penile erection in male rats, besides respectively increasing and decreasing sedation at low (25-200 micrograms kg-1) and high (1600 and 4000 micrograms kg-1) doses and inducing stereotypy from 800 micrograms kg-1 upwards. The DA D2 antagonist, (-) eticlopride (10 and 20 micrograms kg-1), antagonized stretching-yawning and penile erection induced by a low dose of 7-OH-DPAT (50 micrograms kg-1) but not those produced by high doses (1600 and 4000 micrograms kg-1), when stereotyped behaviour, on the other hand, was potently inhibited. Comparative experiments performed with the DA agonist SND 919 gave similar results.
32
63
67
BEHAVIOURAL EFFECTS OF THE DOPAMINE D3 RECEPTOR AGONIST, 7-OH-DPAT IN RATS / Ferrari, Francesca; Giuliani, Daniela. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 32:(1995), pp. 63-67.
Ferrari, Francesca; Giuliani, Daniela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/453063
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