The effect of the synthetic cannabinoid receptor agonist, (-)11-hydroxy-Delta(8)-tetrahydrocannabinol-dymethylheptyl (HU 210), on rat body weight and eating and drinking behaviour was examined. In Experiment 1, the drug (25, 50 or 100 microg/kg), sub-chronically administered for 4 days, produced a dose- and time-dependent loss of body weight that, at the highest dose, was not regained by 7 days after the drug was stopped, and remained markedly below that of vehicle-treated animals. In Experiment 2, food and water intakes, which were evaluated in fasted rats, tested as in Experiment 1, were significantly inhibited only by the dose of 100 microgram/kg, and this effect was still present 7 days after the last injection of the drug. The possibility that the effects observed are not directly dependent on the control of appetite and might be ascribable to stress-related phenomena is discussed.
EFFECTS OF THE CANNABINOID RECEPTOR AGONIST, HU 210, ON INGESTIVE BEHAVIOUR AND BODY WEIGHT OF RATS / Giuliani, Daniela; Ottani, Alessandra; Ferrari, Francesca. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 391(2000), pp. 275-279.
Data di pubblicazione: | 2000 | |
Titolo: | EFFECTS OF THE CANNABINOID RECEPTOR AGONIST, HU 210, ON INGESTIVE BEHAVIOUR AND BODY WEIGHT OF RATS | |
Autore/i: | Giuliani, Daniela; Ottani, Alessandra; Ferrari, Francesca | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 391 | |
Pagina iniziale: | 275 | |
Pagina finale: | 279 | |
Codice identificativo ISI: | WOS:000086083100011 | |
Codice identificativo Scopus: | 2-s2.0-0034677778 | |
Codice identificativo Pubmed: | 10729369 | |
Citazione: | EFFECTS OF THE CANNABINOID RECEPTOR AGONIST, HU 210, ON INGESTIVE BEHAVIOUR AND BODY WEIGHT OF RATS / Giuliani, Daniela; Ottani, Alessandra; Ferrari, Francesca. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 391(2000), pp. 275-279. | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris