The first experiment of the present study investigates the effects induced by sildenafil (1 or 10 mg/kg po) on the copulatory behaviour of intact male rats, categorized, on the basis of seven consecutive mating pretests, as sluggish or normal ejaculators (SE or NE, respectively). The data obtained show that sildenafil modifies both sexual arousal and the ejaculatory mechanisms of copulation, diminishing ejaculation latency in both categories and increasing copulatory efficacy in SE rats; in addition, it reduced the inter-intromission interval in both SE and NE animals and the post-ejaculatory interval only in SE animals. The second experiment, conducted on rats 3 weeks after their castration, shows that sildenafil alone (1 or 10 mg/kg) did not modify copulatory failure. However, 3 months after castration, and 24 h after the last injection of testosterone (25 microg/kg sc) given twice weekly for 4 weeks, sildenafil (1 or 10 mg/kg) ameliorated rat copulatory performance.

MODULATORY ACTIVITY OF SILDENAFIL ON COPULATORY BEHAVIOUR OF BOTH INTACT AND CASTRATED MALE RATS / Ottani, Alessandra; Giuliani, Daniela; Ferrari, Francesca. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 72:(2002), pp. 717-722.

MODULATORY ACTIVITY OF SILDENAFIL ON COPULATORY BEHAVIOUR OF BOTH INTACT AND CASTRATED MALE RATS.

OTTANI, Alessandra;GIULIANI, Daniela;FERRARI, Francesca
2002

Abstract

The first experiment of the present study investigates the effects induced by sildenafil (1 or 10 mg/kg po) on the copulatory behaviour of intact male rats, categorized, on the basis of seven consecutive mating pretests, as sluggish or normal ejaculators (SE or NE, respectively). The data obtained show that sildenafil modifies both sexual arousal and the ejaculatory mechanisms of copulation, diminishing ejaculation latency in both categories and increasing copulatory efficacy in SE rats; in addition, it reduced the inter-intromission interval in both SE and NE animals and the post-ejaculatory interval only in SE animals. The second experiment, conducted on rats 3 weeks after their castration, shows that sildenafil alone (1 or 10 mg/kg) did not modify copulatory failure. However, 3 months after castration, and 24 h after the last injection of testosterone (25 microg/kg sc) given twice weekly for 4 weeks, sildenafil (1 or 10 mg/kg) ameliorated rat copulatory performance.
72
717
722
MODULATORY ACTIVITY OF SILDENAFIL ON COPULATORY BEHAVIOUR OF BOTH INTACT AND CASTRATED MALE RATS / Ottani, Alessandra; Giuliani, Daniela; Ferrari, Francesca. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 72:(2002), pp. 717-722.
Ottani, Alessandra; Giuliani, Daniela; Ferrari, Francesca
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/453045
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