AbstractOBJECTIVES: To determine the incidence of catheter related thrombosis and to test the efficacy of recombinant tissue type plasminogen activator (rt-PA) in preterm infants.STUDY DESIGN: From January 1995 to December 1998, echocardiography was performed in the first few days of life in 76 very low birthweight (< or = 1500 g) infants out of a total of 147 having an umbilical catheter placed. When intracardiac thrombosis was diagnosed, rt-PA infusion was performed.RESULTS: Four infants (5%) developed an intracardiac thrombosis during the first few days of life. In three of them, rt-PA at a dose of 0.4-0.5 mg/kg in a 20-30 minute bolus led to dissolution of the clot. One patient received a three hour infusion after the bolus, at a dose of 0.1 mg/kg/h, with resolution of the thrombus. No systemic effects were observed after rt-PA infusion.CONCLUSIONS: Early thrombosis may occur as a complication of umbilical catheterisation in preterm infants; early echocardiographic detection of this disorder allows complete, safe, and rapid lysis with rt-PA.

EARLY INTRACARDIAC THROMBOSIS IN PRETERM INFANTS AND TROMBOLYSIS WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR / Ferrari, Fabrizio; Vagnarelli, F; Gargano, G; Roversi, Mf; Biagioni, O; Ranzi, A; Cavazzuti, Gb. - In: ARCHIVES OF DISEASE IN CHILDHOOD. - ISSN 0003-9888. - STAMPA. - 85:(2001), pp. 66-69.

EARLY INTRACARDIAC THROMBOSIS IN PRETERM INFANTS AND TROMBOLYSIS WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR

FERRARI, Fabrizio;
2001

Abstract

AbstractOBJECTIVES: To determine the incidence of catheter related thrombosis and to test the efficacy of recombinant tissue type plasminogen activator (rt-PA) in preterm infants.STUDY DESIGN: From January 1995 to December 1998, echocardiography was performed in the first few days of life in 76 very low birthweight (< or = 1500 g) infants out of a total of 147 having an umbilical catheter placed. When intracardiac thrombosis was diagnosed, rt-PA infusion was performed.RESULTS: Four infants (5%) developed an intracardiac thrombosis during the first few days of life. In three of them, rt-PA at a dose of 0.4-0.5 mg/kg in a 20-30 minute bolus led to dissolution of the clot. One patient received a three hour infusion after the bolus, at a dose of 0.1 mg/kg/h, with resolution of the thrombus. No systemic effects were observed after rt-PA infusion.CONCLUSIONS: Early thrombosis may occur as a complication of umbilical catheterisation in preterm infants; early echocardiographic detection of this disorder allows complete, safe, and rapid lysis with rt-PA.
85
66
69
EARLY INTRACARDIAC THROMBOSIS IN PRETERM INFANTS AND TROMBOLYSIS WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR / Ferrari, Fabrizio; Vagnarelli, F; Gargano, G; Roversi, Mf; Biagioni, O; Ranzi, A; Cavazzuti, Gb. - In: ARCHIVES OF DISEASE IN CHILDHOOD. - ISSN 0003-9888. - STAMPA. - 85:(2001), pp. 66-69.
Ferrari, Fabrizio; Vagnarelli, F; Gargano, G; Roversi, Mf; Biagioni, O; Ranzi, A; Cavazzuti, Gb
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/452328
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