Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.

The lutropin/choriocrctnadotropin receptor, a 2002 perspective / Ascoli, M.; Fanelli, Francesca; Segaloff, D.. - In: ENDOCRINE REVIEWS. - ISSN 0163-769X. - ELETTRONICO. - 23:(2002), pp. 141-174. [10.1210/er.23.2.141]

The lutropin/choriocrctnadotropin receptor, a 2002 perspective

FANELLI, Francesca;
2002

Abstract

Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.
23
141
174
The lutropin/choriocrctnadotropin receptor, a 2002 perspective / Ascoli, M.; Fanelli, Francesca; Segaloff, D.. - In: ENDOCRINE REVIEWS. - ISSN 0163-769X. - ELETTRONICO. - 23:(2002), pp. 141-174. [10.1210/er.23.2.141]
Ascoli, M.; Fanelli, Francesca; Segaloff, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/451645
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