In postnatal mammals, the primary site of hematopoiesis is the bone marrow (BM) extravascular compartment. As cells mature, they are released into the vascular compartment through the endothelium and the adventitial layer of mature blood elements. In the BM extravascular space, a dense network of cells constitutes the bone marrow microenvironment (BMM). The BMM provides structural and functional support for the self-renewal and differentiation of hematopoietic progenitor cells as cytokines and cell-to-cell interactions within proliferation niches of the BMM regulate these processes. In this paper, recent advances in understanding the nature of BMM cells are described with a specific focus on mesenchymal progenitors describing their main biological properties and potential clinical applications.

Bone marrow mesenchymal cells: biological properties and clinical applications / Dominici, Massimo; T., Hofmann; E. M., Horwitz. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - STAMPA. - 15:(2001), pp. 28-37.

Bone marrow mesenchymal cells: biological properties and clinical applications.

DOMINICI, Massimo;
2001

Abstract

In postnatal mammals, the primary site of hematopoiesis is the bone marrow (BM) extravascular compartment. As cells mature, they are released into the vascular compartment through the endothelium and the adventitial layer of mature blood elements. In the BM extravascular space, a dense network of cells constitutes the bone marrow microenvironment (BMM). The BMM provides structural and functional support for the self-renewal and differentiation of hematopoietic progenitor cells as cytokines and cell-to-cell interactions within proliferation niches of the BMM regulate these processes. In this paper, recent advances in understanding the nature of BMM cells are described with a specific focus on mesenchymal progenitors describing their main biological properties and potential clinical applications.
2001
15
28
37
Bone marrow mesenchymal cells: biological properties and clinical applications / Dominici, Massimo; T., Hofmann; E. M., Horwitz. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - STAMPA. - 15:(2001), pp. 28-37.
Dominici, Massimo; T., Hofmann; E. M., Horwitz
File in questo prodotto:
File Dimensione Formato  
Dominici et al. JBR 2000.pdf

Solo gestori archivio

Tipologia: Versione pubblicata dall'editore
Dimensione 57.84 kB
Formato Adobe PDF
57.84 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/451312
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 49
social impact