To reduce the level of contamination by bacterial products, ultrafiltration systems have been introduced and validated for their capacity to block the passage of bacterial components reactive to the limulus amoebocyte lysate (LAL) test. In this study, the absorptive capacity of polysulfone membranes undergoing disinfection cycles with free chlorine and peracetic acid were evaluated at various concentrations and contact times. The results of this study implicate a relevant physicochemical derangement of the polysulfone membranes treated with sodium hypochlorite but not with peracetic acid, diluted peracetic acid (Dialox) or Amuchina. The implications for the practical use of ultrafilters are discussed.

Retention of limulus amoebocyte lysate reactive bacterial products by polysulfone dialyzers is affected by the type of disinfectant / Cappelli, Gianni; Inguaggiato, P; Perrone, S; Gervasio, R; Tetta, C; Scialoia, Mg; Albertazzi, Alberto. - In: ASAIO JOURNAL. - ISSN 1058-2916. - STAMPA. - 44:(1998), pp. 587-591.

Retention of limulus amoebocyte lysate reactive bacterial products by polysulfone dialyzers is affected by the type of disinfectant.

CAPPELLI, Gianni;ALBERTAZZI, Alberto
1998-01-01

Abstract

To reduce the level of contamination by bacterial products, ultrafiltration systems have been introduced and validated for their capacity to block the passage of bacterial components reactive to the limulus amoebocyte lysate (LAL) test. In this study, the absorptive capacity of polysulfone membranes undergoing disinfection cycles with free chlorine and peracetic acid were evaluated at various concentrations and contact times. The results of this study implicate a relevant physicochemical derangement of the polysulfone membranes treated with sodium hypochlorite but not with peracetic acid, diluted peracetic acid (Dialox) or Amuchina. The implications for the practical use of ultrafilters are discussed.
44
587
591
Retention of limulus amoebocyte lysate reactive bacterial products by polysulfone dialyzers is affected by the type of disinfectant / Cappelli, Gianni; Inguaggiato, P; Perrone, S; Gervasio, R; Tetta, C; Scialoia, Mg; Albertazzi, Alberto. - In: ASAIO JOURNAL. - ISSN 1058-2916. - STAMPA. - 44:(1998), pp. 587-591.
Cappelli, Gianni; Inguaggiato, P; Perrone, S; Gervasio, R; Tetta, C; Scialoia, Mg; Albertazzi, Alberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/450298
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