The surface deposition of papaverine on the previously emphasized papaverine-Veegum complex has been prepared. In this way, a simple therapeutic system as been obtained. In this system, the drug lays both in the interlayer, as in the complex, and on the carrier surface. Papaverine was released according to a zero order kinetics after the release of an initial rapid dose (priming dose).The in vitro results obtained with the Sartorius Simulator according to Stricker suggested both an absorption according to a zero order kinetics and the acievement in a short time of constant papaverine concentrations in the gastro-intestinal tract.
Montmorillonite as a drug carrier: surface deposition of papaverine on the papaverine-veegum complex / Forni, Flavio; Iannuccelli, Valentina; Coppi, Gilberto; Vandelli, Maria Angela; Cameroni, Riccardo. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - STAMPA. - 126:(1987), pp. 342-346.