The chloramphenicol stearate in the polymorphic Forms A and B was ground in the presence of colloidal silica. The grinding process turned Form A into Form B, and decreased the crystallinity degree of Form B. These conversion and amorphisation processes were related both to the ester/colloidal silica ratio and to the grinding time. After grinding in the presence of colloidal silica, the chloramphenicol stearate showed an in vitro enzymatic hydrolysis rate value higher than those of a commercial sample (Form B) and of Form B in the physical mixtures.
The grinding of the polymorphic forms of chloramphenicol stearic ester in the presence of colloidal silica / Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Cameroni, Riccardo. - In: ACTA PHARMACEUTICA SUECICA. - ISSN 0001-6675. - STAMPA. - 25:(1988), pp. 173-180.
The grinding of the polymorphic forms of chloramphenicol stearic ester in the presence of colloidal silica
FORNI, Flavio;COPPI, Gilberto;IANNUCCELLI, Valentina;VANDELLI, Maria Angela;CAMERONI, Riccardo
1988
Abstract
The chloramphenicol stearate in the polymorphic Forms A and B was ground in the presence of colloidal silica. The grinding process turned Form A into Form B, and decreased the crystallinity degree of Form B. These conversion and amorphisation processes were related both to the ester/colloidal silica ratio and to the grinding time. After grinding in the presence of colloidal silica, the chloramphenicol stearate showed an in vitro enzymatic hydrolysis rate value higher than those of a commercial sample (Form B) and of Form B in the physical mixtures.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
