Ethylene vinyl acetate pellets were loaded by swelling with chloroformic solutions of tolbutamide. The energy dispersive X-ray analysis showed different concentrations of the tolbutamide sulfur in the pellet sections according to the loading time. The concentration peaks might depend on a drug sieving process as the solution flow reaches a less swollen inner area. Another possible explanation of these concentration profiles is that they could be a result of thesolvent evaporation process. The concentration distribution of the drug becomes homogenous only after the complete swelling of all the polymer.

Distribution of drugs in polymers loaded by swelling / Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 78(1989), pp. 25-27. [10.1002/jps.2600780108]

Distribution of drugs in polymers loaded by swelling

FORNI, Flavio;COPPI, Gilberto;IANNUCCELLI, Valentina;VANDELLI, Maria Angela;BERNABEI, Maria Teresa
1989

Abstract

Ethylene vinyl acetate pellets were loaded by swelling with chloroformic solutions of tolbutamide. The energy dispersive X-ray analysis showed different concentrations of the tolbutamide sulfur in the pellet sections according to the loading time. The concentration peaks might depend on a drug sieving process as the solution flow reaches a less swollen inner area. Another possible explanation of these concentration profiles is that they could be a result of thesolvent evaporation process. The concentration distribution of the drug becomes homogenous only after the complete swelling of all the polymer.
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25
27
Distribution of drugs in polymers loaded by swelling / Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 78(1989), pp. 25-27. [10.1002/jps.2600780108]
Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/450239
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