The agonist potency of 2-cia-methyl-5-dimethylaminomethyl-1,3-oxathiolane-3-traqns-oxide methiodide and its two enantiomers were detemined in vivo at muscarinic M1 and M2 receptors. The results indicate a selectivity of 5-8 fold for M1 receptors, confirming the M1 profile of the oxathiolane nucleus.
Determination of Muscarinic Agonist Potencies at M1 and M2 Receptors in Pithed Rat / Angeli, P.; Brasili, Livio; Gulini, U.; Cantalamessa, F.. - In: PHARMACEUTICAL AND PHARMACOLOGICAL LETTERS. - ISSN 0939-9488. - STAMPA. - 2:(1993), pp. 207-209.
Determination of Muscarinic Agonist Potencies at M1 and M2 Receptors in Pithed Rat
BRASILI, Livio;
1993
Abstract
The agonist potency of 2-cia-methyl-5-dimethylaminomethyl-1,3-oxathiolane-3-traqns-oxide methiodide and its two enantiomers were detemined in vivo at muscarinic M1 and M2 receptors. The results indicate a selectivity of 5-8 fold for M1 receptors, confirming the M1 profile of the oxathiolane nucleus.
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