The synthesis and antimuscarinic activity on M1, M 2 and M3 tissues of cis- and trans-2-phenyl-2-cyclohexyl-4-[(dimethylamino)-methyl]-1,3-dithiolane methiodides (1 and 2)are described. Our results show that compound 1 is a potent and Mr1 selective muscarinic antagonist.
Synthesis, Pharmacological Evaluation and Selectivity Profile of Isomeric 2-Phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dithiolane Methiodide as Potent Antimuscarinic Agents / Angeli, P.; Brasili, Livio; Gulini, U.; Marucci, G.; Paparelli, F.. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - STAMPA. - 2:(1992), pp. 74-81.
Synthesis, Pharmacological Evaluation and Selectivity Profile of Isomeric 2-Phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dithiolane Methiodide as Potent Antimuscarinic Agents
BRASILI, Livio;
1992
Abstract
The synthesis and antimuscarinic activity on M1, M 2 and M3 tissues of cis- and trans-2-phenyl-2-cyclohexyl-4-[(dimethylamino)-methyl]-1,3-dithiolane methiodides (1 and 2)are described. Our results show that compound 1 is a potent and Mr1 selective muscarinic antagonist.
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