We report the case of a 69-year-old man with a 7-month history of severe progressive supranuclear gaze palsy associated with mild cognitive decline and sleep disturbances, but not parkinsonism. After a period spent consulting a range of different specialists, the appearance of brachial myoclonus prompted his referral to a movement disorders specialist. Duodenum biopsy confirmed the suspicion of neuro-Whipple disease. Antibiotic therapy was started but the delay in the diagnosis proved fatal to this patient. This noteworthy case shows unusual neurological features of a rare but treatable disease, often misdiagnosed as progressive supranuclear palsy
Progressive supranuclear gaze palsy without parkinsonism: a case of neuro-Whipple / Magherini, A; Pentore, R; Grandi, M; Leone, Me; Nichelli, Paolo Frigio. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - STAMPA. - 13:(2007), pp. 449-452.
Progressive supranuclear gaze palsy without parkinsonism: a case of neuro-Whipple
NICHELLI, Paolo Frigio
2007
Abstract
We report the case of a 69-year-old man with a 7-month history of severe progressive supranuclear gaze palsy associated with mild cognitive decline and sleep disturbances, but not parkinsonism. After a period spent consulting a range of different specialists, the appearance of brachial myoclonus prompted his referral to a movement disorders specialist. Duodenum biopsy confirmed the suspicion of neuro-Whipple disease. Antibiotic therapy was started but the delay in the diagnosis proved fatal to this patient. This noteworthy case shows unusual neurological features of a rare but treatable disease, often misdiagnosed as progressive supranuclear palsy
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