This paper describes a new method for the evaluation of conductimetric data collected during the in-line monitoring of the coupling step in solid-phase peptide synthesis. The control scheme relies on a feed-forward artificial neural network algorithm which can predict the final yield of the reaction within its initial 5 min by analyzing the conductivity signal profile. The yield values predicted by the artificial neural network algorithm result in good accordance with the data obtained by the commonly used ninhydrin test.

A Novel Algorithm for the Coupling Control in Solid Phase Peptide Synthesis / Bagno, A.; Bicciato, Silvio; Dettin, M.; DI BELLO, C.. - In: JOURNAL OF PEPTIDE RESEARCH. - ISSN 1397-002X. - STAMPA. - 50:(1997), pp. 231-237.

A Novel Algorithm for the Coupling Control in Solid Phase Peptide Synthesis

BICCIATO, Silvio;
1997-01-01

Abstract

This paper describes a new method for the evaluation of conductimetric data collected during the in-line monitoring of the coupling step in solid-phase peptide synthesis. The control scheme relies on a feed-forward artificial neural network algorithm which can predict the final yield of the reaction within its initial 5 min by analyzing the conductivity signal profile. The yield values predicted by the artificial neural network algorithm result in good accordance with the data obtained by the commonly used ninhydrin test.
1997
50
231
237
A Novel Algorithm for the Coupling Control in Solid Phase Peptide Synthesis / Bagno, A.; Bicciato, Silvio; Dettin, M.; DI BELLO, C.. - In: JOURNAL OF PEPTIDE RESEARCH. - ISSN 1397-002X. - STAMPA. - 50:(1997), pp. 231-237.
Bagno, A.; Bicciato, Silvio; Dettin, M.; DI BELLO, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/421459
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