The use of anti-GD1a IgG antibody, as a diagnostic marker of GBS in generalized forms, is described in a patient with with acute facial diplegia and hyperreflexia and the usefulness of anti-ganglioside antibody assays is highlighted. Tests for IgG and IgM antibodies against GM2, GM1, GM1b, GalNAc-GD1a, GD1b, GT1a and GQ1b were negative whereas thin-layer chromatography with immunostaining confirmed the presence of anti-GD1a antibody.An enzyme-linked immunosorbent assay revealed elevated anti-GD1a IgG antibody titer of 2000 (normal <500) in serum obtained on day 6. On day 180, there were no residual neurological abnormalities and seventeen months after onset, titer of anti-GD1a IgG antibody was 500.
Post-infectious acute ataxia and facial diplegia associated with anti-GD1a IgG antibody / Galassi, G; Susuki, K; Quaglino, Daniela; Yuki, N.. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - STAMPA. - 11:11(2004), pp. 790-791. [10.1111/j.1468-1331.2004.00975.x]
Post-infectious acute ataxia and facial diplegia associated with anti-GD1a IgG antibody
QUAGLINO, Daniela;
2004
Abstract
The use of anti-GD1a IgG antibody, as a diagnostic marker of GBS in generalized forms, is described in a patient with with acute facial diplegia and hyperreflexia and the usefulness of anti-ganglioside antibody assays is highlighted. Tests for IgG and IgM antibodies against GM2, GM1, GM1b, GalNAc-GD1a, GD1b, GT1a and GQ1b were negative whereas thin-layer chromatography with immunostaining confirmed the presence of anti-GD1a antibody.An enzyme-linked immunosorbent assay revealed elevated anti-GD1a IgG antibody titer of 2000 (normal <500) in serum obtained on day 6. On day 180, there were no residual neurological abnormalities and seventeen months after onset, titer of anti-GD1a IgG antibody was 500.
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