The application of molecular modelling and regression analysis techniques to the complexes between the ET(A) and ET(B) receptors and a series of C-terminal endothelin hexapeptide antagonists allowed the identification of the structural determinants for recognition and the quantitative elucidation of the receptor structure-affinity/selectivity relationships.
Quantitative structure-affinity/selectivity relationship analysis on three-dimensional models of the complexes between the ETA and ETB receptors and C-terminal endothelin hexapeptide antagonists / Menziani, Maria Cristina; Cocchi, Marina; Fanelli, Francesca; DE BENEDETTI, Pier Giuseppe. - In: JOURNAL OF MOLECULAR STRUCTURE. THEOCHEM. - ISSN 0166-1280. - STAMPA. - 333:(1995), pp. 243-248.
Quantitative structure-affinity/selectivity relationship analysis on three-dimensional models of the complexes between the ETA and ETB receptors and C-terminal endothelin hexapeptide antagonists
MENZIANI, Maria Cristina;COCCHI, Marina;FANELLI, Francesca;DE BENEDETTI, Pier Giuseppe
1995
Abstract
The application of molecular modelling and regression analysis techniques to the complexes between the ET(A) and ET(B) receptors and a series of C-terminal endothelin hexapeptide antagonists allowed the identification of the structural determinants for recognition and the quantitative elucidation of the receptor structure-affinity/selectivity relationships.
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