The interaction of two biliar acids (chenodeoxycholic acid and cholic acid) with 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) in solution and in the solid state was studied using different techniques. The formation of an inclusion complex with a 1 : 1 stoichiometry was suggested by the phase solubility studies. Both differential scanning calorimetry and X-ray diffractometry exhibited the amorphous state of the complex. The inclusion of both biliar acids into the HP beta CD cavity was confirmed by the C-13-NMR studies. Cholic acid showed a weaker affinity with respect to chenodeoxycholic acid probably owing to the presence of a hydroxyl group on C(12) (12 alpha) close to the complexation site.

THE INTERACTION OF BILIAR ACIDS WITH 2-HYDROXYPROPYL-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID STATE / Mucci, Adele; Schenetti, Luisa; Salvioli, Gianfranco; Ventura, Paolo; Vandelli, Maria Angela; Forni, Flavio. - In: JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY. - ISSN 0923-0750. - STAMPA. - 26:(1996), pp. 233-241.

THE INTERACTION OF BILIAR ACIDS WITH 2-HYDROXYPROPYL-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID STATE

MUCCI, Adele;SCHENETTI, Luisa;SALVIOLI, Gianfranco;VENTURA, Paolo;VANDELLI, Maria Angela;FORNI, Flavio
1996-01-01

Abstract

The interaction of two biliar acids (chenodeoxycholic acid and cholic acid) with 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) in solution and in the solid state was studied using different techniques. The formation of an inclusion complex with a 1 : 1 stoichiometry was suggested by the phase solubility studies. Both differential scanning calorimetry and X-ray diffractometry exhibited the amorphous state of the complex. The inclusion of both biliar acids into the HP beta CD cavity was confirmed by the C-13-NMR studies. Cholic acid showed a weaker affinity with respect to chenodeoxycholic acid probably owing to the presence of a hydroxyl group on C(12) (12 alpha) close to the complexation site.
26
233
241
THE INTERACTION OF BILIAR ACIDS WITH 2-HYDROXYPROPYL-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID STATE / Mucci, Adele; Schenetti, Luisa; Salvioli, Gianfranco; Ventura, Paolo; Vandelli, Maria Angela; Forni, Flavio. - In: JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY. - ISSN 0923-0750. - STAMPA. - 26:(1996), pp. 233-241.
Mucci, Adele; Schenetti, Luisa; Salvioli, Gianfranco; Ventura, Paolo; Vandelli, Maria Angela; Forni, Flavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/310873
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