EnglishThe interaction of two biliar acids (chenodeoxycholic acid and cholic acid) with 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) in solution and in the solid state was studied using different techniques. The formation of an inclusion complex with a 1 : 1 stoichiometry was suggested by the phase solubility studies. Both differential scanning calorimetry and X-ray diffractometry exhibited the amorphous state of the complex. The inclusion of both biliar acids into the HP beta CD cavity was confirmed by the C-13-NMR studies. Cholic acid showed a weaker affinity with respect to chenodeoxycholic acid probably owing to the presence of a hydroxyl group on C(12) (12 alpha) close to the complexation site.
| Data di pubblicazione: | 1996 |
| Titolo: | THE INTERACTION OF BILIAR ACIDS WITH 2-HYDROXYPROPYL-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID STATE |
| Autore/i: | Mucci, Adele; Schenetti, Luisa; Salvioli, Gianfranco; Ventura, Paolo; Vandelli, Maria Angela; Forni, Flavio |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 26 |
| Pagina iniziale: | 233 |
| Pagina finale: | 241 |
| Codice identificativo ISI: | WOS:A1996WN42700006 |
| Codice identificativo Scopus: | 2-s2.0-0030511285 |
| Citazione: | THE INTERACTION OF BILIAR ACIDS WITH 2-HYDROXYPROPYL-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID STATE / Mucci, Adele; Schenetti, Luisa; Salvioli, Gianfranco; Ventura, Paolo; Vandelli, Maria Angela; Forni, Flavio. - In: JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY. - ISSN 0923-0750. - STAMPA. - 26(1996), pp. 233-241. |
| Tipologia | Articolo su rivista |
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