Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of proliferation and differentiation of hematopoietic cells and in the pathogenesis of many diseases, including multiple myeloma. This study pursues a way to interfere with IL-6 pathway in an attempt to modulate its biological activity. Here we describe the rational design and biological evaluation of peptides able to antagonize the murine IL-6 activity by interfering with IL-6 Receptor alpha in 7TD1 cells, a IL-6-dependent B-cell line. Of the peptide tested, only Guess 4a is capable of interfering with IL-6 transducing pathway, therefore inducing growth arrest and apoptosis of 7TD1 cells.
Development of an IL-6 antagonist peptide that induces apoptosis in IL-6 dependent 7TD1 cells / Manfredini, Rossella; Tenedini, Elena; M., Siena; Tagliafico, Enrico; Montanari, Monica; Grande, Alexis; ZANOCCO MARANI, Tommaso; C., Poligani; Zini, Roberta; A., Bergamaschi; DE RIENZO, Francesca; DE BENEDETTI, Pier Giuseppe; Menziani, Maria Cristina; Ferrari, Sergio. - In: PEPTIDES. - ISSN 0079-0753. - STAMPA. - 24:8(2003), pp. 1207-1220. [10.1016/j.peptides.2003.06.005]
Development of an IL-6 antagonist peptide that induces apoptosis in IL-6 dependent 7TD1 cells.
MANFREDINI, Rossella;TENEDINI, Elena;TAGLIAFICO, Enrico;MONTANARI, Monica;GRANDE, Alexis;ZANOCCO MARANI, Tommaso;ZINI, Roberta;DE RIENZO, Francesca;DE BENEDETTI, Pier Giuseppe;MENZIANI, Maria Cristina;FERRARI, Sergio
2003
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of proliferation and differentiation of hematopoietic cells and in the pathogenesis of many diseases, including multiple myeloma. This study pursues a way to interfere with IL-6 pathway in an attempt to modulate its biological activity. Here we describe the rational design and biological evaluation of peptides able to antagonize the murine IL-6 activity by interfering with IL-6 Receptor alpha in 7TD1 cells, a IL-6-dependent B-cell line. Of the peptide tested, only Guess 4a is capable of interfering with IL-6 transducing pathway, therefore inducing growth arrest and apoptosis of 7TD1 cells.File | Dimensione | Formato | |
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