The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ACTH-(1-24), 160 micrograms/kg; c) blood reinfusion; d) ACTH-(1-24), 160 micrograms/kg; c) blood reinfusion; d) ACTH-(1-24), with saline 5 min after bleeding died within 0.05 h. On the other hand, the treatment with ACTH-(1-24) induced an almost complete and sustained recovery of cardiovascular and respiratory functions associated with a survival time of 44 +/- 18 h, while four of six rats reinfused with the withdrawn blood were still alive 15 days later. The time-lapse between bleeding and treatment was of crucial importance, and neither ACTH-(1-24) injection nor blood reinfusion had any effect if performed 25 min after bleeding. However, treatment with ACTH-(1-24) shortly after bleeding (5 min) greatly improved the effect of a later blood reinfusion. These data indicate that ACTH-(1-24) can prolong survival and permit the time-lapse between blood loss and blood reinfusion to be extended.
Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective / Guarini, Salvatore; S., Tagliavini; Bazzani, Carla; Ferrari, William; Bertolini, Alfio. - In: CRITICAL CARE MEDICINE. - ISSN 0090-3493. - STAMPA. - 18(1990), pp. 862-865.
Data di pubblicazione: | 1990 |
Titolo: | Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective |
Autore/i: | Guarini, Salvatore; S., Tagliavini; Bazzani, Carla; Ferrari, William; Bertolini, Alfio |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 18 |
Pagina iniziale: | 862 |
Pagina finale: | 865 |
Codice identificativo ISI: | WOS:A1990DU13700014 |
Codice identificativo Scopus: | 2-s2.0-0025321929 |
Codice identificativo Pubmed: | 2379400 |
Citazione: | Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective / Guarini, Salvatore; S., Tagliavini; Bazzani, Carla; Ferrari, William; Bertolini, Alfio. - In: CRITICAL CARE MEDICINE. - ISSN 0090-3493. - STAMPA. - 18(1990), pp. 862-865. |
Tipologia | Articolo su rivista |
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