A new five-step route to the CD45 protein tyrosine phosphatase inhibitor (Z)-pulchellalactam is presented. Key steps are the CuCl-bipyridine catalysed atom transfer radical cyclization of an appropriate allyl ,-dichloroacetate and the subsequent dehydrochlorination/prototropic rearrangement of the resulting dichlorolactone.
A novel short approach to (Z)-pulchellalactam through Transition-Metal-Catalized Atom-Transfer Radical Cyclization of 1-isopropylprop-2-enyl dichloroacetate / F., Felluga; Ghelfi, Franco; Pagnoni, Ugo Maria; Af, Parsons; M., Pattarozzi; Roncaglia, Fabrizio; E., Valentin. - In: SYNTHESIS. - ISSN 0039-7881. - STAMPA. - 00:12(2007), pp. 1882-1886. [10.1055/s-2007-983709]
A novel short approach to (Z)-pulchellalactam through Transition-Metal-Catalized Atom-Transfer Radical Cyclization of 1-isopropylprop-2-enyl dichloroacetate
GHELFI, Franco;PAGNONI, Ugo Maria;RONCAGLIA, Fabrizio;
2007
Abstract
A new five-step route to the CD45 protein tyrosine phosphatase inhibitor (Z)-pulchellalactam is presented. Key steps are the CuCl-bipyridine catalysed atom transfer radical cyclization of an appropriate allyl ,-dichloroacetate and the subsequent dehydrochlorination/prototropic rearrangement of the resulting dichlorolactone.
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