We determined whole blood lead and cadmium levels, and serum selenium levels in patients with sporadic amyotrophic lateral sclerosis and age- and sex-matched controls. Disability due to the disease directly correlated with lead levels, and there was a strong inverse correlation with selenium concentrations. Lead and selenium concentrations tended to be similar in the cases and controls, bath in the study population as a whole and after the removal from the analysis of the patients with the highest degree of disability. In the patients with limited disability, cadmium concentrations were higher than in the controls. Our findings lend limited support to a possible involvement of cadmium, but not lead, in the etiology of sporadic amyotrophic lateral sclerosis, and strongly suggest that short-term indicators of exposure are inadequate to investigate the relationship between selenium and the disease.

Lead, cadmium, and selenium in blood of patients with sporadic amyotrophic lateral sclerosis / VINCETI, Marco; D., Guidetti; BERGOMI, Margherita; E., Caselgrandi; R., Vivoli; M., Olmi; L., Rinaldi; ROVESTI, Sergio; F., Solime. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - STAMPA. - 18:(1997), pp. 87-92.

Lead, cadmium, and selenium in blood of patients with sporadic amyotrophic lateral sclerosis.

VINCETI, Marco;BERGOMI, Margherita;ROVESTI, Sergio;
1997

Abstract

We determined whole blood lead and cadmium levels, and serum selenium levels in patients with sporadic amyotrophic lateral sclerosis and age- and sex-matched controls. Disability due to the disease directly correlated with lead levels, and there was a strong inverse correlation with selenium concentrations. Lead and selenium concentrations tended to be similar in the cases and controls, bath in the study population as a whole and after the removal from the analysis of the patients with the highest degree of disability. In the patients with limited disability, cadmium concentrations were higher than in the controls. Our findings lend limited support to a possible involvement of cadmium, but not lead, in the etiology of sporadic amyotrophic lateral sclerosis, and strongly suggest that short-term indicators of exposure are inadequate to investigate the relationship between selenium and the disease.
18
87
92
Lead, cadmium, and selenium in blood of patients with sporadic amyotrophic lateral sclerosis / VINCETI, Marco; D., Guidetti; BERGOMI, Margherita; E., Caselgrandi; R., Vivoli; M., Olmi; L., Rinaldi; ROVESTI, Sergio; F., Solime. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - STAMPA. - 18:(1997), pp. 87-92.
Vinceti, Marco; D., Guidetti; Bergomi, Margherita; E., Caselgrandi; R., Vivoli; M., Olmi; L., Rinaldi; Rovesti, Sergio; F., Solime
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310663
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 52
social impact