Background and Objective. Although in recent years anaplastic large-cell lymphoma (ALCL) has emerged as a distinct clinlco-pathological entity, a gold standard for treatment has still not been defined. Goals of our histologic, phenotypic and clinical study were to present clinical findings, treatment outcome and survival rates of a small, but highly homogeneously treat ed, series of patients. Design and Methods. From April 1991, 36 newly diagnosed adult patients with systemic ALCL CD30(+), entered a prospective non-randomized trial in one of the institutions participating in a GISL (Gruppo Italiano per lo studio dei Linfomi) study and were treated with a MOPP/EBV/CAD hybrid scheme. Chemotherapy (CHT) was administered every 28 days, for a total of 6 cycles. After CHT, 19 patients received radiation therapy (RT) to the site of previously involved fields. Kaplan and Meier and log-rank tests were used for statistical analysis. Results. The overall complete remission rate was 78%, the partial remission rate was 6%. The overall survival rate at 74 months was 69%. No statistically significant differences in response or survival rates were noted comparing ALCL-HL and -CT subgroups, T+ Null- and B- subtypes, or ALCL-HL and -CT, with different phenotypes. In the analysis of patients with T+ Null phenotype treated with CHT+RT in comparison with B-ALCL patients who had the same treatment, we observed statistically significant differences in the survival rate (p=0.048). No prognostic factors predictive of response or survival were identified. Interpretation and Conclusions. Our results show that using MOPP/ABV/CAD the results, in terms of remission rate and survival, are similar to those obtained with 3(rd) generation CHT regimens. The diagnosis of T and Null ALCL is the mast important prognostic factor, because it Is associated with a very good survival, even in patients with a high prognostic index. Finally, we believe that longer follow-ups are needed to evaluate long-term survival and toxicity with different treatments. (C)1999, Ferrata Storti Foundation.

Clinical characteristics, treatment outcome and survival of 36 adult patients with primary anaplastic large cell lymphoma. Gruppo Italiano per lo Studio dei Linfomi (GISL) / G., Longo; C., Fiorani; Sacchi, Stefano; V., Callea; M., Lombardo; Federico, Massimo; C., Stelitano; F., Angrilli; D., Vallisa; P. G., Gobbi; F., Ilariucci; A., Frassoldati; M., Petrini; V., Silingardi. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 84 (5):(1999), pp. 425-430.

Clinical characteristics, treatment outcome and survival of 36 adult patients with primary anaplastic large cell lymphoma. Gruppo Italiano per lo Studio dei Linfomi (GISL).

SACCHI, Stefano;FEDERICO, Massimo;
1999

Abstract

Background and Objective. Although in recent years anaplastic large-cell lymphoma (ALCL) has emerged as a distinct clinlco-pathological entity, a gold standard for treatment has still not been defined. Goals of our histologic, phenotypic and clinical study were to present clinical findings, treatment outcome and survival rates of a small, but highly homogeneously treat ed, series of patients. Design and Methods. From April 1991, 36 newly diagnosed adult patients with systemic ALCL CD30(+), entered a prospective non-randomized trial in one of the institutions participating in a GISL (Gruppo Italiano per lo studio dei Linfomi) study and were treated with a MOPP/EBV/CAD hybrid scheme. Chemotherapy (CHT) was administered every 28 days, for a total of 6 cycles. After CHT, 19 patients received radiation therapy (RT) to the site of previously involved fields. Kaplan and Meier and log-rank tests were used for statistical analysis. Results. The overall complete remission rate was 78%, the partial remission rate was 6%. The overall survival rate at 74 months was 69%. No statistically significant differences in response or survival rates were noted comparing ALCL-HL and -CT subgroups, T+ Null- and B- subtypes, or ALCL-HL and -CT, with different phenotypes. In the analysis of patients with T+ Null phenotype treated with CHT+RT in comparison with B-ALCL patients who had the same treatment, we observed statistically significant differences in the survival rate (p=0.048). No prognostic factors predictive of response or survival were identified. Interpretation and Conclusions. Our results show that using MOPP/ABV/CAD the results, in terms of remission rate and survival, are similar to those obtained with 3(rd) generation CHT regimens. The diagnosis of T and Null ALCL is the mast important prognostic factor, because it Is associated with a very good survival, even in patients with a high prognostic index. Finally, we believe that longer follow-ups are needed to evaluate long-term survival and toxicity with different treatments. (C)1999, Ferrata Storti Foundation.
84 (5)
425
430
Clinical characteristics, treatment outcome and survival of 36 adult patients with primary anaplastic large cell lymphoma. Gruppo Italiano per lo Studio dei Linfomi (GISL) / G., Longo; C., Fiorani; Sacchi, Stefano; V., Callea; M., Lombardo; Federico, Massimo; C., Stelitano; F., Angrilli; D., Vallisa; P. G., Gobbi; F., Ilariucci; A., Frassoldati; M., Petrini; V., Silingardi. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 84 (5):(1999), pp. 425-430.
G., Longo; C., Fiorani; Sacchi, Stefano; V., Callea; M., Lombardo; Federico, Massimo; C., Stelitano; F., Angrilli; D., Vallisa; P. G., Gobbi; F., Ilariucci; A., Frassoldati; M., Petrini; V., Silingardi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310641
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