The relation between the trace element selenium and the etiology of cancer in humans remains elusive and intriguing, despite the number of epidemiologic studies published on the topic. We address some methodologic issues, such as misclassification of exposure, particularly to single selenium compounds, effect modification, confounding, and other sources of bias, which may explain the inconsistencies in the literature. We also review the results of cohort studies, which have yielded either inverse or null or direct associations between selenium exposure and subsequent cancer risk. To date, no beneficial effect on cancer incidence at major sites, including prostate cancer, has emerged from the Finnish program begun in 1984 to increase the average selenium intake in its population. Populations exposed to unusually high or low levels of environmental selenium might offer unique opportunities to investigate if selenium exposure is related to the etiology of human cancer.

The epidemiology of selenium and human cancer / Vinceti, Marco; Rovesti, Sergio; Bergomi, Margherita; Vivoli, Gianfranco. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 86:(2000), pp. 105-118.

The epidemiology of selenium and human cancer

VINCETI, Marco;ROVESTI, Sergio;BERGOMI, Margherita;VIVOLI, Gianfranco
2000

Abstract

The relation between the trace element selenium and the etiology of cancer in humans remains elusive and intriguing, despite the number of epidemiologic studies published on the topic. We address some methodologic issues, such as misclassification of exposure, particularly to single selenium compounds, effect modification, confounding, and other sources of bias, which may explain the inconsistencies in the literature. We also review the results of cohort studies, which have yielded either inverse or null or direct associations between selenium exposure and subsequent cancer risk. To date, no beneficial effect on cancer incidence at major sites, including prostate cancer, has emerged from the Finnish program begun in 1984 to increase the average selenium intake in its population. Populations exposed to unusually high or low levels of environmental selenium might offer unique opportunities to investigate if selenium exposure is related to the etiology of human cancer.
86
105
118
The epidemiology of selenium and human cancer / Vinceti, Marco; Rovesti, Sergio; Bergomi, Margherita; Vivoli, Gianfranco. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 86:(2000), pp. 105-118.
Vinceti, Marco; Rovesti, Sergio; Bergomi, Margherita; Vivoli, Gianfranco
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310365
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 45
social impact