The interaction of ursodeoxycholic acid (UDCA) with beta-cyclodextrin (beta-CD) is investigated through one and two-dimensional (ROESY) NMR spectroscopy. The relative orientation of host and guest is unequivocally established: the aliphatic side chain of UDCA enters the torus of B-CD on the side of the secondary hydroxy groups.
The interaction of ursodeoxycholic acid (UDCA) with β-cyclodextrin (β-CD) is investigated through one-and two-dimensional (ROESY) NMR spectroscopy. The relative orientation of host and guest is unequivocally established: the aliphatic side chain of UDCA enters the torus of β-CD on the side of the secondary hydroxy groups.
One- and two-dimensional NMR study of complexation of ursodeoxycholic acid with beta-cyclodextrin / Mucci, Adele; Schenetti, Luisa; Vandelli, Maria Angela; Forni, Flavio; Ventura, Paolo; Salvioli, Gianfranco. - In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II. - ISSN 0300-9580. - STAMPA. - 1996:11(1996), pp. 2347-2349. [10.1039/P29960002347]
One- and two-dimensional NMR study of complexation of ursodeoxycholic acid with beta-cyclodextrin
MUCCI, Adele;SCHENETTI, Luisa;VANDELLI, Maria Angela;FORNI, Flavio;VENTURA, Paolo;SALVIOLI, Gianfranco
1996
Abstract
The interaction of ursodeoxycholic acid (UDCA) with β-cyclodextrin (β-CD) is investigated through one-and two-dimensional (ROESY) NMR spectroscopy. The relative orientation of host and guest is unequivocally established: the aliphatic side chain of UDCA enters the torus of β-CD on the side of the secondary hydroxy groups.
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