EnglishA computational approach based upon rigid-body docking, ad hoc filtering, and cluster analysis has been carried out to predict likely interfaces in LHR homodimers. Quaternary structure predictions emphasize the role of helices 4, 5 and 6, with prominence to helix 4, in mediating inter-monomer interactions. Intermolecular interactions essentially involve the transmembrane domains rather than the hydrophilic loops and do not implicate disulfide bridges.Collectively, molecular dynamics simulations on the isolated receptor and computational modeling of LHR homodimerization suggest that mutation-induced LHR activation favors H4-H4 contacts involving the highly conserved W491 from both the receptors monomers.
Dimerization of the lutropin receptor: Insights from computational modeling / Fanelli, Francesca. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - ELETTRONICO. - 260(2007), pp. 59-64.
| Data di pubblicazione: | 2007 | |
| Titolo: | Dimerization of the lutropin receptor: Insights from computational modeling | |
| Autore/i: | Fanelli, Francesca | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.mce.2005.12.054 | |
| Rivista: | ||
| Volume: | 260 | |
| Pagina iniziale: | 59 | |
| Pagina finale: | 64 | |
| Codice identificativo ISI: | WOS:000243202300008 | |
| Codice identificativo Scopus: | 2-s2.0-33751203259 | |
| Codice identificativo Pubmed: | 17052834 | |
| Citazione: | Dimerization of the lutropin receptor: Insights from computational modeling / Fanelli, Francesca. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - ELETTRONICO. - 260(2007), pp. 59-64. | |
| Tipologia | Articolo su rivista |
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