The effects of a focal lesion induced by endothelin-1 (ETI1, 0.8 mu g/0.8 mu l) on superoxide dismutase (SOD) were studied in the neostriatum of male rats. SOD activity was analyzed at several time intervals (5, 20, 60 min, 4, 24 h and 7 days) after the lesion. No significant changes were observed early after the injection, but SOD activity started to rise significantly at the 60-min time interval reaching a peak 24 h after the injection. In a second experiment the volume of ET-1-induced lesion was evaluated following treatments which induce variations of SOD activity. ET-1 caused a large lesion (9.20 +/- 1.32 mm(3)) in the neostriatum 24 h after the injection that was 3-fold greater than that observed 1 h after. Rats treated with the SOD inhibitor diethyldithiocarbamate showed a lesion equivalent to that observed 1 h after ET-1 injection, suggesting that SOD may be involved in the maturation of ET-1-induced neuronal damage.
Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection / Biagini, Giuseppe; D., Sala; Zini, Isabella. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 190(1995), pp. 212-216.
Data di pubblicazione: | 1995 | |
Titolo: | Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection. | |
Autore/i: | Biagini, Giuseppe; D., Sala; Zini, Isabella | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 190 | |
Pagina iniziale: | 212 | |
Pagina finale: | 216 | |
Codice identificativo ISI: | WOS:A1995QZ77300017 | |
Codice identificativo Scopus: | 2-s2.0-0028989323 | |
Codice identificativo Pubmed: | 7637895 | |
Citazione: | Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection / Biagini, Giuseppe; D., Sala; Zini, Isabella. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 190(1995), pp. 212-216. | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris