The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 (R) analyzer using bull blood.
Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid / A., Ammazzalorso; R., Amoroso; Baraldi, Mario; G., Bettoni; Braghiroli, Daniela; B., De Filippis; L., Giampietro; M. L., Tricca; Vezzalini, Francesca. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - STAMPA. - 40:9(2005), pp. 918-921. [10.1016/j.ejmech.2005.03.022]
Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid
BARALDI, Mario;BRAGHIROLI, Daniela;VEZZALINI, Francesca
2005
Abstract
The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 (R) analyzer using bull blood.
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