Interferon-alpha has been widely used in chronic hepatitis C, but controlled studies with intramuscular interferon-beta are lacking. We therefore performed a prospective, double-blind, randomized study comparing intramuscular IFN-alpha and -beta in patients with chronic hepatitis C. Sixty patients were randomly assigned to receive 3 MU thrice weekly intramuscularly of either recombinant IFN-alpha or leukocyte IFN-alpha or fibroblast IFN-beta for six months. Nine of 20 patients (45.0%) in the recombinant IFN, 5/19 (26.3%) in the leukocyte IFN, and none in the IFN-beta group had a complete response during therapy (recombinant IFN vs IFN-beta: P < 0.01). Only in IFN-alpha-treated patients, was infection with a single HCV genotype (type 2a or 2b) associated with significantly better long-term outcome. IFN-alpha is useful in chronic hepatitis C while intramuscular IFN-beta interferon does not exert any beneficial effect. This is probably due to an insufficient bioavailability of IFN-beta when given intramuscularly.

Alpha but not beta interferon is useful in chronic active hepatitis due to hepatitis C virus - A prospective, double-blind, randomized study / Villa, Erica; P., Trande; Grottola, Antonella; Manenti, Federico; P., Buttafoco; Am, Rebecchi; T., Stroffolini; F., Callea; A., Merighi; L., Camellini; P., Zoboli; R., Cosenza; Loria, Paola; L., Miglioli; Carulli, Nicola; R., Iori. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - STAMPA. - 41(1996), pp. 1241-1247.

Alpha but not beta interferon is useful in chronic active hepatitis due to hepatitis C virus - A prospective, double-blind, randomized study

VILLA, Erica;GROTTOLA, Antonella;MANENTI, Federico;LORIA, Paola;CARULLI, Nicola;
1996

Abstract

Interferon-alpha has been widely used in chronic hepatitis C, but controlled studies with intramuscular interferon-beta are lacking. We therefore performed a prospective, double-blind, randomized study comparing intramuscular IFN-alpha and -beta in patients with chronic hepatitis C. Sixty patients were randomly assigned to receive 3 MU thrice weekly intramuscularly of either recombinant IFN-alpha or leukocyte IFN-alpha or fibroblast IFN-beta for six months. Nine of 20 patients (45.0%) in the recombinant IFN, 5/19 (26.3%) in the leukocyte IFN, and none in the IFN-beta group had a complete response during therapy (recombinant IFN vs IFN-beta: P < 0.01). Only in IFN-alpha-treated patients, was infection with a single HCV genotype (type 2a or 2b) associated with significantly better long-term outcome. IFN-alpha is useful in chronic hepatitis C while intramuscular IFN-beta interferon does not exert any beneficial effect. This is probably due to an insufficient bioavailability of IFN-beta when given intramuscularly.
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1241
1247
Alpha but not beta interferon is useful in chronic active hepatitis due to hepatitis C virus - A prospective, double-blind, randomized study / Villa, Erica; P., Trande; Grottola, Antonella; Manenti, Federico; P., Buttafoco; Am, Rebecchi; T., Stroffolini; F., Callea; A., Merighi; L., Camellini; P., Zoboli; R., Cosenza; Loria, Paola; L., Miglioli; Carulli, Nicola; R., Iori. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - STAMPA. - 41(1996), pp. 1241-1247.
Villa, Erica; P., Trande; Grottola, Antonella; Manenti, Federico; P., Buttafoco; Am, Rebecchi; T., Stroffolini; F., Callea; A., Merighi; L., Camellini; P., Zoboli; R., Cosenza; Loria, Paola; L., Miglioli; Carulli, Nicola; R., Iori
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310100
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