Dihydroxydibutylether (DHBE, 900 mg/day, in divided doses) was given to 13 patients with radiolucent gallstones. Bile lipid composition and bile saturation were studied before treatment and after 1 and 2 months of therapy. Bile was collected by duodenal intubation (after cerulein-induced gallbladder contraction) in each patient, and biliary lipids were estimated with standard laboratory techniques. The results of this study showed that DHBE treatment was associated with a significant (p less than 0.01) reduction of bile saturation with cholesterol (saturation index: 1.37 +/- 0.39 before treatment, 1.14 +/- 0.35 after 1 month, and 1.08 +/- 0.29 after 2 months). The possible mechanism of this effect and the clinical relevance are discussed.

The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones / PONZ DE LEON, Maurizio; Loria, Paola; R., Iori; I., Piccagli; N., Carulli; A., Belvisi; M., Matergi. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY. - ISSN 0174-4879. - STAMPA. - 21:(1983), pp. 37-40.

The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones

PONZ DE LEON, Maurizio;LORIA, Paola;
1983

Abstract

Dihydroxydibutylether (DHBE, 900 mg/day, in divided doses) was given to 13 patients with radiolucent gallstones. Bile lipid composition and bile saturation were studied before treatment and after 1 and 2 months of therapy. Bile was collected by duodenal intubation (after cerulein-induced gallbladder contraction) in each patient, and biliary lipids were estimated with standard laboratory techniques. The results of this study showed that DHBE treatment was associated with a significant (p less than 0.01) reduction of bile saturation with cholesterol (saturation index: 1.37 +/- 0.39 before treatment, 1.14 +/- 0.35 after 1 month, and 1.08 +/- 0.29 after 2 months). The possible mechanism of this effect and the clinical relevance are discussed.
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The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones / PONZ DE LEON, Maurizio; Loria, Paola; R., Iori; I., Piccagli; N., Carulli; A., Belvisi; M., Matergi. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY. - ISSN 0174-4879. - STAMPA. - 21:(1983), pp. 37-40.
PONZ DE LEON, Maurizio; Loria, Paola; R., Iori; I., Piccagli; N., Carulli; A., Belvisi; M., Matergi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/310074
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