Dihydroxydibutylether (DHBE, 900 mg/day, in divided doses) was given to 13 patients with radiolucent gallstones. Bile lipid composition and bile saturation were studied before treatment and after 1 and 2 months of therapy. Bile was collected by duodenal intubation (after cerulein-induced gallbladder contraction) in each patient, and biliary lipids were estimated with standard laboratory techniques. The results of this study showed that DHBE treatment was associated with a significant (p less than 0.01) reduction of bile saturation with cholesterol (saturation index: 1.37 +/- 0.39 before treatment, 1.14 +/- 0.35 after 1 month, and 1.08 +/- 0.29 after 2 months). The possible mechanism of this effect and the clinical relevance are discussed.
|Data di pubblicazione:||1983|
|Titolo:||The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones|
|Autore/i:||M. PONZ DE LEON PISANI; P. LORIA; R. IORI; I. PICCAGLI; N. CARULLI; A. BELVISI; M. MATERGI|
|Codice identificativo ISI:||WOS:A1983QJ90900005|
|Codice identificativo Scopus:||2-s2.0-0020695868|
|Citazione:||The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones / M. PONZ DE LEON PISANI; P. LORIA; R. IORI; I. PICCAGLI; N. CARULLI; A. BELVISI; M. MATERGI. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY. - ISSN 0174-4879. - STAMPA. - 21(1983), pp. 37-40.|
|Tipologia||Articolo su rivista|
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