Polypeptide sequences encoded by some exons of the human tropoelastin gene (EDP, elastin-derived peptide) have been analysed for their ability to coacervate and to self-assembly. The great majority of them were shown to form organized structures, but only a few were indeed able to coacervate. Negative staining and rotary shadowing transmission electron microscopy showed the polypeptides to adopt a variety of supramolecular organization, from filaments, as those typical of tropoelastin, to amyloid-like fibers. The results obtained gave significant insight to the possible roles played by specific polypeptide sequences of tropoelastin.
Dissection of human tropoelastin: Supramolecular organization of polypeptide sequences coded by particular exons / A., Pepe; Guerra, Deanna; B., Bochicchio; Quaglino, Daniela; Gheduzzi, Dealba; Ronchetti, Ivonne; A. M., Tamburro. - In: MATRIX BIOLOGY. - ISSN 0945-053X. - STAMPA. - 24:2(2005), pp. 96-109. [10.1016/j.matbio.2005.01.004]
Dissection of human tropoelastin: Supramolecular organization of polypeptide sequences coded by particular exons
GUERRA, Deanna;QUAGLINO, Daniela;GHEDUZZI, Dealba;RONCHETTI, Ivonne;
2005
Abstract
Polypeptide sequences encoded by some exons of the human tropoelastin gene (EDP, elastin-derived peptide) have been analysed for their ability to coacervate and to self-assembly. The great majority of them were shown to form organized structures, but only a few were indeed able to coacervate. Negative staining and rotary shadowing transmission electron microscopy showed the polypeptides to adopt a variety of supramolecular organization, from filaments, as those typical of tropoelastin, to amyloid-like fibers. The results obtained gave significant insight to the possible roles played by specific polypeptide sequences of tropoelastin.
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