A few epidemiologic studies have suggested that consumption of drinking water with high trihalomethane content increases the risk of cancer. We investigated the mortality of a cohort of 5144 residents in Guastalla, northern Italy, who were supplied tap water with high chloroform and trihalomethane content between 1965 and 1987. Using death rates of a nearby community as reference rates, the standardized mortality ratio from all cancers between 1987 and 1999 was slightly increased for both males (1.2, 95% confidence interval 1.1-1.4) and females (1.1, 95% confidence interval 1.0-1.3). This was mainly due to a higher mortality from stomach, liver, lung, prostate and bladder cancer in males and from stomach, pancreas, breast and ovarian cancer and lymphocytic leukaemia in females. We also noted excess mortality from melanoma in both males and females. Overall, our findings were consistent with an association between trihalomethane exposure and increased cancer risk at some sites. However, the point estimates were statistically imprecise, due to the limited number of deaths for some site-specific cancers. In addition, we were unable to rule out the possibility of confounding due to smoking and other life-style factors with regard to some of the excess rates.

A retrospective cohort study of trihalometane exposure through drinking water and cancer mortality in northern Italy / Vinceti, Marco; Fantuzzi, Guglielmina; L., Monici; M., Cassinadri; Predieri, Guerrino; Aggazzotti, Gabriella. - In: SCIENCE OF THE TOTAL ENVIRONMENT. - ISSN 0048-9697. - STAMPA. - 330:(2004), pp. 47-53.

A retrospective cohort study of trihalometane exposure through drinking water and cancer mortality in northern Italy.

VINCETI, Marco;FANTUZZI, Guglielmina;PREDIERI, Guerrino;AGGAZZOTTI, Gabriella
2004

Abstract

A few epidemiologic studies have suggested that consumption of drinking water with high trihalomethane content increases the risk of cancer. We investigated the mortality of a cohort of 5144 residents in Guastalla, northern Italy, who were supplied tap water with high chloroform and trihalomethane content between 1965 and 1987. Using death rates of a nearby community as reference rates, the standardized mortality ratio from all cancers between 1987 and 1999 was slightly increased for both males (1.2, 95% confidence interval 1.1-1.4) and females (1.1, 95% confidence interval 1.0-1.3). This was mainly due to a higher mortality from stomach, liver, lung, prostate and bladder cancer in males and from stomach, pancreas, breast and ovarian cancer and lymphocytic leukaemia in females. We also noted excess mortality from melanoma in both males and females. Overall, our findings were consistent with an association between trihalomethane exposure and increased cancer risk at some sites. However, the point estimates were statistically imprecise, due to the limited number of deaths for some site-specific cancers. In addition, we were unable to rule out the possibility of confounding due to smoking and other life-style factors with regard to some of the excess rates.
330
47
53
A retrospective cohort study of trihalometane exposure through drinking water and cancer mortality in northern Italy / Vinceti, Marco; Fantuzzi, Guglielmina; L., Monici; M., Cassinadri; Predieri, Guerrino; Aggazzotti, Gabriella. - In: SCIENCE OF THE TOTAL ENVIRONMENT. - ISSN 0048-9697. - STAMPA. - 330:(2004), pp. 47-53.
Vinceti, Marco; Fantuzzi, Guglielmina; L., Monici; M., Cassinadri; Predieri, Guerrino; Aggazzotti, Gabriella
File in questo prodotto:
File Dimensione Formato  
Vinceti_2004.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 86.01 kB
Formato Adobe PDF
86.01 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/309971
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 25
social impact