Eye movements up to seven hours after ketamine injection were recorded in Long-Evans rats by means of a phase detection search coil apparatus. A flutter-like oculomotor pattern immeditely appeared after drug administration, lasting about one hour; it was characterized by unidirectional slow eye movements with superimposed bursts of saccades. While saccadic dynamics was always within the normal range, the eyes were unable to maintain a steady post-saccadic position. Every saccade was followed by a quick drift back towards the initial position. As the rat aroused, paroxysmal ocular motility stopped and spontaneous well isolated, now bidirectional saccades appeared. The post-saccadic drift persisted. Ocular flutter-like behavior could result from a sustained activation of the saccade generator, whereas impairment of gaze holding might be due to the neural integrator suppression.

Spatio-temporal pattern of eye movements induced by ketamine in the rat / Gp, Biral; Benassi, Carlo; Lui, Fausta; R., Corazza. - STAMPA. - (1994), pp. 315-324.

Spatio-temporal pattern of eye movements induced by ketamine in the rat

BENASSI, Carlo;LUI, Fausta;
1994

Abstract

Eye movements up to seven hours after ketamine injection were recorded in Long-Evans rats by means of a phase detection search coil apparatus. A flutter-like oculomotor pattern immeditely appeared after drug administration, lasting about one hour; it was characterized by unidirectional slow eye movements with superimposed bursts of saccades. While saccadic dynamics was always within the normal range, the eyes were unable to maintain a steady post-saccadic position. Every saccade was followed by a quick drift back towards the initial position. As the rat aroused, paroxysmal ocular motility stopped and spontaneous well isolated, now bidirectional saccades appeared. The post-saccadic drift persisted. Ocular flutter-like behavior could result from a sustained activation of the saccade generator, whereas impairment of gaze holding might be due to the neural integrator suppression.
VISUAL AND OCULOMOTOR FUNCTIONS: ADVANCES IN EYE MOVEMENT RESEARCH
0444818081
Elsevier
PAESI BASSI
Spatio-temporal pattern of eye movements induced by ketamine in the rat / Gp, Biral; Benassi, Carlo; Lui, Fausta; R., Corazza. - STAMPA. - (1994), pp. 315-324.
Gp, Biral; Benassi, Carlo; Lui, Fausta; R., Corazza
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/309822
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