We describe a case of persistent polyclonal B-cell lymphocytosis (PPBL) studied by morphological, immunological, cytogenetic and molecular analysis. PPBL is a rare lymphoproliferative disorder with an unclear natural history. Although a few cases of malignancies are observed during PPBL, this disorder is usually considered to be an indolent syndrome. A longer follow-up in a larger number of patients is needed in order to clarify the natural history of PPBL and its potential to transform into a malignancy. As PPBL is a rare disease, establishing an international PPBL registry could be the most effective way to understand the natural history of this disease and to discover its etiologic factors. (C) 2000 Elsevier Science Ltd. All rights reserved.

Persistent polyclonal B lymphocytosis: morphological, immunological, cytogenetic and molecular analysis of an Italian case / S., Tonelli; P., Vanzanelli; Sacchi, Stefano; C., Fiorani; I., Castelli; P., Temperani; G., Bonacorsi. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 24:10(2000), pp. 877-879. [10.1016/S0145-2126(00)00069-2]

Persistent polyclonal B lymphocytosis: morphological, immunological, cytogenetic and molecular analysis of an Italian case

SACCHI, Stefano;
2000

Abstract

We describe a case of persistent polyclonal B-cell lymphocytosis (PPBL) studied by morphological, immunological, cytogenetic and molecular analysis. PPBL is a rare lymphoproliferative disorder with an unclear natural history. Although a few cases of malignancies are observed during PPBL, this disorder is usually considered to be an indolent syndrome. A longer follow-up in a larger number of patients is needed in order to clarify the natural history of PPBL and its potential to transform into a malignancy. As PPBL is a rare disease, establishing an international PPBL registry could be the most effective way to understand the natural history of this disease and to discover its etiologic factors. (C) 2000 Elsevier Science Ltd. All rights reserved.
2000
24
10
877
879
Persistent polyclonal B lymphocytosis: morphological, immunological, cytogenetic and molecular analysis of an Italian case / S., Tonelli; P., Vanzanelli; Sacchi, Stefano; C., Fiorani; I., Castelli; P., Temperani; G., Bonacorsi. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 24:10(2000), pp. 877-879. [10.1016/S0145-2126(00)00069-2]
S., Tonelli; P., Vanzanelli; Sacchi, Stefano; C., Fiorani; I., Castelli; P., Temperani; G., Bonacorsi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/309664
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