Synaptosomes obtained from rat striata lesioned by central injection of endothelin-1 (ET-1) were analyzed for the levels of lipid peroxidation products, the susceptibility to lipid peroxidation, the phospholipid and free fatty acid composition and the activity of Na+,K+-ATPase one hour after ET-1 treatment. The intrastriatal injection of ET-1 promoted an increase of endogenous thiobarbituric reactive substances (TEARS), as index of free radical mediated lipid damage, and a greater susceptibility to iron/ascorbate-induced lipid peroxidation. The pattern of free fatty acids showed a significant decrease of arachidonic and docosahexaenoic acid consequent to ET-1 treatment. The analysis of lipid composition showed a significant loss of phospholipids: among phospholipid species, sphingomyelin and phosphatidylethanolamine plasmalogen were particularly reduced by ET-1 treatment. The activity of membrane-bound Na+,K+-ATPase was also significantly reduced in synaptosomes obtained from ET-1 lesioned striata. Taken together these results indicate a significant modification of synaptosomal membrane of ET-1 treated rat striata, possibly due to a free radical mediated damage.
EFFECT OF ENDOTHELIN-1 INDUCED ISCHEMIA ON PEROXIDATIVE DAMAGE AND MEMBRANE-PROPERTIES IN RAT STRIATUM SYNAPTOSOMES / P., Viani; Zini, Isabella; G., Cervato; Biagini, Giuseppe; Agnati, Luigi Francesco; B., Cestaro. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - STAMPA. - 20(1995), pp. 689-695.
Data di pubblicazione: | 1995 | |
Titolo: | EFFECT OF ENDOTHELIN-1 INDUCED ISCHEMIA ON PEROXIDATIVE DAMAGE AND MEMBRANE-PROPERTIES IN RAT STRIATUM SYNAPTOSOMES | |
Autore/i: | P., Viani; Zini, Isabella; G., Cervato; Biagini, Giuseppe; Agnati, Luigi Francesco; B., Cestaro | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 20 | |
Pagina iniziale: | 689 | |
Pagina finale: | 695 | |
Codice identificativo ISI: | WOS:A1995RE59400009 | |
Codice identificativo Scopus: | 2-s2.0-0029030788 | |
Codice identificativo Pubmed: | 7566365 | |
Citazione: | EFFECT OF ENDOTHELIN-1 INDUCED ISCHEMIA ON PEROXIDATIVE DAMAGE AND MEMBRANE-PROPERTIES IN RAT STRIATUM SYNAPTOSOMES / P., Viani; Zini, Isabella; G., Cervato; Biagini, Giuseppe; Agnati, Luigi Francesco; B., Cestaro. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - STAMPA. - 20(1995), pp. 689-695. | |
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