The hydroalcoholic extract of Maytenus krukovii bark was investigated for its in vitro mutageno-protective activities by means of the Ames Salmonella/microsome assay. The extract showed an inhibitory effect in both T98 and T100 strains against the mutagenic activity of promutagen 2-aminoanthracene but was not protective against directly acting mutagens sodium azide and 2-nitrofluorene. When tested as a radical scavenger and antioxidant it produced a dose-dependent inhibition. The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum. (c) 2006 Elsevier B.V. All rights reserved.
Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark / R., Bruni; D., Rossi; M., Muzzoli; Romagnoli, Carlo; G., Paganetto; E., Besco; F., Choquecillo; K., Peralta; W. S., Lora; G., Sacchetti. - In: FITOTERAPIA. - ISSN 1971-551X. - STAMPA. - 77:7-8(2006), pp. 538-545. [10.1016/j.fitote.2006.06.009]
Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark
ROMAGNOLI, Carlo;
2006-01-01
Abstract
The hydroalcoholic extract of Maytenus krukovii bark was investigated for its in vitro mutageno-protective activities by means of the Ames Salmonella/microsome assay. The extract showed an inhibitory effect in both T98 and T100 strains against the mutagenic activity of promutagen 2-aminoanthracene but was not protective against directly acting mutagens sodium azide and 2-nitrofluorene. When tested as a radical scavenger and antioxidant it produced a dose-dependent inhibition. The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum. (c) 2006 Elsevier B.V. All rights reserved.
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