Background and aims: Herpesviruses infect the liver and cause minor hepatitis. Our aim is to verify the presence of herpesviruses in the liver from hepatitis C patients and the possible influence of these viruses in the liver disease. Methods: We searched for herpesvirus DNA in liver biopsies from patients with hepatitis C and from a control group without hepatitis by means of nested polymerase chain reaction. Serological investigations were carried out as well. Results: Thirty-four liver specimens from hepatitis C patients were examined, 12 of which (35.3%) were positive for at least one herpesvirus DNA, whereas among the 19 control specimens only two were positive (10.5%; P = 0.049). Liver biopsies from seven patients, three with acute hepatitis of unknown origin, three with non-alcoholic steatohepatitis and one with autoimmune hepatitis were also investigated and three positive samples were found. Conclusions: The prevalence of herpesvirus DNA was found higher in patients with hepatitis C than in individuals without hepatitis. The influence of herpesviruses on the clinical course of hepatitis C is considered. (C) 1999 Elsevier Science B.V. All rights reserved.
Herpesvirus DNA is frequently detected in liver tissue from hepatitis C patients / Cermelli, Claudio; M., Concari; P., Pietrosemoli; M., Meacci; Sabbatini, Anna Maria Teresa; A., Divincenzo; Carubbi, Francesca; Loria, Paola; A., Bagni; Carulli, Nicola; Portolani, Marinella. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - STAMPA. - 14:(1999), pp. 9-16. [10.1016/S1386-6532(99)00045-1]
Herpesvirus DNA is frequently detected in liver tissue from hepatitis C patients
CERMELLI, Claudio;SABBATINI, Anna Maria Teresa;CARUBBI, Francesca;LORIA, Paola;CARULLI, Nicola;PORTOLANI, Marinella
1999-01-01
Abstract
Background and aims: Herpesviruses infect the liver and cause minor hepatitis. Our aim is to verify the presence of herpesviruses in the liver from hepatitis C patients and the possible influence of these viruses in the liver disease. Methods: We searched for herpesvirus DNA in liver biopsies from patients with hepatitis C and from a control group without hepatitis by means of nested polymerase chain reaction. Serological investigations were carried out as well. Results: Thirty-four liver specimens from hepatitis C patients were examined, 12 of which (35.3%) were positive for at least one herpesvirus DNA, whereas among the 19 control specimens only two were positive (10.5%; P = 0.049). Liver biopsies from seven patients, three with acute hepatitis of unknown origin, three with non-alcoholic steatohepatitis and one with autoimmune hepatitis were also investigated and three positive samples were found. Conclusions: The prevalence of herpesvirus DNA was found higher in patients with hepatitis C than in individuals without hepatitis. The influence of herpesviruses on the clinical course of hepatitis C is considered. (C) 1999 Elsevier Science B.V. All rights reserved.
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