The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, beta-cyclodextrin (CD) and 2-hydroxypropyl-beta-cyclodextrin (HPCD), studied in D2O solution with different NMR techniques (1H, 13C NMR, ROESY experiments, NMR titrations), shows the existence of multiple equilibria involving 1:1 and 2:1 guest–host complexes.
Evidence of the existence of 2:1 guest-host complexes between diclofenac and cyclodextrins in D2O solutions. A 1H and 13C NMR study on diclofenac/beta-cyclodextrin and diclofenac/2-hydroxypropyl-beta-cyclodextrin systems / Mucci, Adele; Schenetti, Luisa; Vandelli, Maria Angela; Ruozi, Barbara; Forni, Flavio. - In: JOURNAL OF CHEMICAL RESEARCH. - ISSN 0308-2350. - STAMPA. - S:(1999), pp. 414-415. [10.1039/a902526j]
Evidence of the existence of 2:1 guest-host complexes between diclofenac and cyclodextrins in D2O solutions. A 1H and 13C NMR study on diclofenac/beta-cyclodextrin and diclofenac/2-hydroxypropyl-beta-cyclodextrin systems
MUCCI, Adele;SCHENETTI, Luisa;VANDELLI, Maria Angela;RUOZI, Barbara;FORNI, Flavio
1999
Abstract
The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, beta-cyclodextrin (CD) and 2-hydroxypropyl-beta-cyclodextrin (HPCD), studied in D2O solution with different NMR techniques (1H, 13C NMR, ROESY experiments, NMR titrations), shows the existence of multiple equilibria involving 1:1 and 2:1 guest–host complexes.
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