In this study we compared the kinetics of phosphocreatine (PCr) and P(i) recovery, and their dependency on cytosolic pH in 38 normal individuals. Spectra were acquired during rest, work and recovery. A time resolution of 10 s was used to obtain detailed information. The kinetics of PCr and P(i) recovery almost overlapped when the lowest value of cytosolic pH reached during recovery (termed the minimum pH) was < 6.95, while they were completely dissociated when the minimum pH was > 6.95. This result is interpreted as indirect in vivo evidence of the kinetic control exerted by ADP on mitochondrial oxidation. Our results represent a rationale for new experimental conditions to be used in clinical routine studies of pathologies due to primary or secondary mitochondrial malfunction.
IN-VIVO ASSESSMENT OF MITOCHONDRIAL FUNCTIONALITY IN HUMAN GASTROCNEMIUS-MUSCLE BY P-31 MRS - THE ROLE OF PH IN THE EVALUATION OF PHOSPHOCREATINE AND INORGANIC-PHOSPHATE RECOVERIES FROM EXERCISE / S., Iotti; R., Lodi; Frassineti, Chiara; Zaniol, Paolo; B., Barbiroli. - In: NMR IN BIOMEDICINE. - ISSN 0952-3480. - STAMPA. - 6(1993), pp. 248-253.
Data di pubblicazione: | 1993 |
Titolo: | IN-VIVO ASSESSMENT OF MITOCHONDRIAL FUNCTIONALITY IN HUMAN GASTROCNEMIUS-MUSCLE BY P-31 MRS - THE ROLE OF PH IN THE EVALUATION OF PHOSPHOCREATINE AND INORGANIC-PHOSPHATE RECOVERIES FROM EXERCISE |
Autore/i: | S., Iotti; R., Lodi; Frassineti, Chiara; Zaniol, Paolo; B., Barbiroli |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 6 |
Pagina iniziale: | 248 |
Pagina finale: | 253 |
Codice identificativo ISI: | WOS:A1993LX33800003 |
Codice identificativo Scopus: | 2-s2.0-0027633260 |
Codice identificativo Pubmed: | 8217526 |
Citazione: | IN-VIVO ASSESSMENT OF MITOCHONDRIAL FUNCTIONALITY IN HUMAN GASTROCNEMIUS-MUSCLE BY P-31 MRS - THE ROLE OF PH IN THE EVALUATION OF PHOSPHOCREATINE AND INORGANIC-PHOSPHATE RECOVERIES FROM EXERCISE / S., Iotti; R., Lodi; Frassineti, Chiara; Zaniol, Paolo; B., Barbiroli. - In: NMR IN BIOMEDICINE. - ISSN 0952-3480. - STAMPA. - 6(1993), pp. 248-253. |
Tipologia | Articolo su rivista |
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