Flavonoids are natural substances with a lot of biological activities, including the antioxidant one. Their use in pharmaceutical field is, however, limited by their aqueous insolubility. As the formation of the inclusion complexes can improve their solubility in water, the flavonoids hesperetin, hesperidin, naringenin and naringin have been complexed with beta-cyclodextrin (beta-CD) by the coprecipitation method and studied in solution and in solid state by NMR, FT-IR, differential scanning calorimetry and X-ray techniques, The effects of complexation on the chemical shifts of the internal and external protons of beta-CD in the presence of each flavonoid were observed. (C) 2002 Elsevier Science B.V. All rights reserved.

Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation / R., Ficarra; S., Tommasini; D., Raneri; M. L., Calabro; M. R., Di Bella; Rustichelli, Cecilia; Gamberini, Maria Cristina; P., Ficarra. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 29 (6)(2002), pp. 1005-1014.

Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation

RUSTICHELLI, Cecilia;GAMBERINI, Maria Cristina;
2002

Abstract

Flavonoids are natural substances with a lot of biological activities, including the antioxidant one. Their use in pharmaceutical field is, however, limited by their aqueous insolubility. As the formation of the inclusion complexes can improve their solubility in water, the flavonoids hesperetin, hesperidin, naringenin and naringin have been complexed with beta-cyclodextrin (beta-CD) by the coprecipitation method and studied in solution and in solid state by NMR, FT-IR, differential scanning calorimetry and X-ray techniques, The effects of complexation on the chemical shifts of the internal and external protons of beta-CD in the presence of each flavonoid were observed. (C) 2002 Elsevier Science B.V. All rights reserved.
29 (6)
1005
1014
Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation / R., Ficarra; S., Tommasini; D., Raneri; M. L., Calabro; M. R., Di Bella; Rustichelli, Cecilia; Gamberini, Maria Cristina; P., Ficarra. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 29 (6)(2002), pp. 1005-1014.
R., Ficarra; S., Tommasini; D., Raneri; M. L., Calabro; M. R., Di Bella; Rustichelli, Cecilia; Gamberini, Maria Cristina; P., Ficarra
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/307834
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