A novel application of (PhO)(3)P-Cl-2 chemistry to the synthesis of 2-substituted and 2,3-disubstituted pyrroles from N-allylamides is illustrated. A mild procedure is Used to generate the imino chloride intermediates, which are subsequently cyclized to pyrroles. The products are smoothly obtained in moderate to good overall yields.
The triphenyl phosphite-chlorine reagent in the synthesis of pyrroles from N-allylamides / Spaggiari, Alberto; Vaccari, Daniele; Davoli, Paolo; Prati, Fabio. - In: SYNTHESIS. - ISSN 0039-7881. - STAMPA. - 37:6(2006), pp. 995-998. [10.1055/s-2006-926365]
The triphenyl phosphite-chlorine reagent in the synthesis of pyrroles from N-allylamides
SPAGGIARI, Alberto;VACCARI, Daniele;DAVOLI, Paolo;PRATI, Fabio
2006
Abstract
A novel application of (PhO)(3)P-Cl-2 chemistry to the synthesis of 2-substituted and 2,3-disubstituted pyrroles from N-allylamides is illustrated. A mild procedure is Used to generate the imino chloride intermediates, which are subsequently cyclized to pyrroles. The products are smoothly obtained in moderate to good overall yields.Pubblicazioni consigliate
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