Ethyl trans-3-(trifluoromethyl)pyroglutamate 1 is synthesized in excellent yield; racemic 1 is enzymatically resolved with alpha-chymotrypsin-catalyzed hydrolysis affording both the enantiomerically pure enantiomers. The absolute configuration is established by X-ray analysis of the corresponding trichloroethylester. Copyright
Synthesis, enzymatic resolution and absolute configuration of ethyl trans-3-(trifluoromethyl)pyroglutamate / Antolini, Luciano; Forni, Arrigo; Moretti, Irene; Prati, Fabio; E., Laurent; D., Gestmann. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 7:(1996), pp. 3309-3314.
Synthesis, enzymatic resolution and absolute configuration of ethyl trans-3-(trifluoromethyl)pyroglutamate
ANTOLINI, Luciano;FORNI, Arrigo;MORETTI, Irene;PRATI, Fabio;
1996
Abstract
Ethyl trans-3-(trifluoromethyl)pyroglutamate 1 is synthesized in excellent yield; racemic 1 is enzymatically resolved with alpha-chymotrypsin-catalyzed hydrolysis affording both the enantiomerically pure enantiomers. The absolute configuration is established by X-ray analysis of the corresponding trichloroethylester. Copyright
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