The effect of cocaine (7.5, 15 and 30 mg/kg) administered in acute or subchronic mode, on the mating behaviour of sexually active male rats varied in a dose- and mode-dependent manner. Regardless of mode of treatment, 30 mg/kg markedly impaired the rats´ copulatory ability and impairment continued for a week after suspension of subchronic treatment. An acute dose of 15 mg/kg reduced intromission frequency, while in subchronic mode it also reduced ejaculation latency. Mount frequency was increased by 7.5 and 15 mg/kg, but only on first injection. In the case of sexually-naive male rats, acute administration of cocaine (3-30 mg/kg) stimulated penile erections at 7.5 mg/kg and motor hyperactivity at all doses. (-) Eticlopride (0.025 and 0.05 mg/kg), a DA D-2 antagonist, counteracted cocaine-induced motor hyperactivity but not penile erection, which it enhanced. (-)Eticlopride at the same doses also antagonized cocaine potentiation of lisuride (0.2 mg/kg)-induced behavioural effects. When male rats treated with subchronic cocaine (15 mg/kg) were injected with the DA D-2 agonist SND 919 (0.1 mg/kg), they displayed a more marked stretching-yawning behaviour than control animals receiving SND 919 at the same dose. The involvement of DA D-2 receptors in cocaine-induced effects is suggested.

INVOLVEMENT OF DOPAMINE D2 RECEPTORS IN THE EFFECT OF COCAINE ON SEXUAL BEHAVIOUR AND STRETCHING-YAWNING OF MALE RATS / Ferrari, Francesca; Giuliani, Daniela; .,. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - STAMPA. - 36:(1997), pp. 769-777.

INVOLVEMENT OF DOPAMINE D2 RECEPTORS IN THE EFFECT OF COCAINE ON SEXUAL BEHAVIOUR AND STRETCHING-YAWNING OF MALE RATS.

FERRARI, Francesca;GIULIANI, Daniela;
1997

Abstract

The effect of cocaine (7.5, 15 and 30 mg/kg) administered in acute or subchronic mode, on the mating behaviour of sexually active male rats varied in a dose- and mode-dependent manner. Regardless of mode of treatment, 30 mg/kg markedly impaired the rats´ copulatory ability and impairment continued for a week after suspension of subchronic treatment. An acute dose of 15 mg/kg reduced intromission frequency, while in subchronic mode it also reduced ejaculation latency. Mount frequency was increased by 7.5 and 15 mg/kg, but only on first injection. In the case of sexually-naive male rats, acute administration of cocaine (3-30 mg/kg) stimulated penile erections at 7.5 mg/kg and motor hyperactivity at all doses. (-) Eticlopride (0.025 and 0.05 mg/kg), a DA D-2 antagonist, counteracted cocaine-induced motor hyperactivity but not penile erection, which it enhanced. (-)Eticlopride at the same doses also antagonized cocaine potentiation of lisuride (0.2 mg/kg)-induced behavioural effects. When male rats treated with subchronic cocaine (15 mg/kg) were injected with the DA D-2 agonist SND 919 (0.1 mg/kg), they displayed a more marked stretching-yawning behaviour than control animals receiving SND 919 at the same dose. The involvement of DA D-2 receptors in cocaine-induced effects is suggested.
36
769
777
INVOLVEMENT OF DOPAMINE D2 RECEPTORS IN THE EFFECT OF COCAINE ON SEXUAL BEHAVIOUR AND STRETCHING-YAWNING OF MALE RATS / Ferrari, Francesca; Giuliani, Daniela; .,. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - STAMPA. - 36:(1997), pp. 769-777.
Ferrari, Francesca; Giuliani, Daniela; .,
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/307057
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