Treatment of 9-methyladenine (9-MeAd) with cis[PtL2(NO3)(2)] (1) (L = PMe2Ph) in a 2:1 molar ratio generated the bis(adduct) cis-[PtL2(9-MeAd)(2)](NO3)(2) (2), which was isolated and fully characterized by multinuclear (H-1, P-31, C-13, Pt-195 and N-15) NMR analysis, which showed that the two nucleobases are selectively coordinated through the N1 atom. Small amounts of a mono(adduct) cis-[PtL2(S)(9-MeAd)](2+) (3) (S = solvent) and of a diplatinated species cis-[L2Pt(S){9MeAd(-H)]PtL2](3+) (4) are formed in DMSO solution when 9MeAd is present in smaller quantities than 1. Complex 3 is platinated at N1, with a solvent molecule representing the fourth ligand around the metal center. Complex 4 contains an adenine molecule deprotonated and platinated at N1,N6,N7, with two cis-L2Pt units bonded to nitrogen atom N1 and to nitrogen atoms N6 and N7, respectively. With increasing relative concentration of the nucleobase, both complexes 3 and 4 progressively convert into the bis(adduct) 2, the only species detectable in solution when the Ad/Pt molar ratio is 2:1. The trinuclear compound cis-[L2Pt{9-MeAd(-H)}](3)(NO3)(3) (5).

Coordination modes of 9-methyladenine in cis-platinum(II) complexes with dimethyl(phenyl)phosphanes as ancillary ligands - Synthesis and characterization of cis-[PtL2(9-MeAd)(2)](NO3)(2),cis-[PtL2{9-MeAd(-H)}](3)(NO3)(3), and cis-[L2Pt{9-MeAd(-H)}PtL2](NO3)(3) / B., Longato; L., Pasquato; Mucci, Adele; Schenetti, Luisa. - In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. - ISSN 1434-1948. - STAMPA. - 2003:1(2003), pp. 128-137.

Coordination modes of 9-methyladenine in cis-platinum(II) complexes with dimethyl(phenyl)phosphanes as ancillary ligands - Synthesis and characterization of cis-[PtL2(9-MeAd)(2)](NO3)(2),cis-[PtL2{9-MeAd(-H)}](3)(NO3)(3), and cis-[L2Pt{9-MeAd(-H)}PtL2](NO3)(3)

MUCCI, Adele;SCHENETTI, Luisa
2003

Abstract

Treatment of 9-methyladenine (9-MeAd) with cis[PtL2(NO3)(2)] (1) (L = PMe2Ph) in a 2:1 molar ratio generated the bis(adduct) cis-[PtL2(9-MeAd)(2)](NO3)(2) (2), which was isolated and fully characterized by multinuclear (H-1, P-31, C-13, Pt-195 and N-15) NMR analysis, which showed that the two nucleobases are selectively coordinated through the N1 atom. Small amounts of a mono(adduct) cis-[PtL2(S)(9-MeAd)](2+) (3) (S = solvent) and of a diplatinated species cis-[L2Pt(S){9MeAd(-H)]PtL2](3+) (4) are formed in DMSO solution when 9MeAd is present in smaller quantities than 1. Complex 3 is platinated at N1, with a solvent molecule representing the fourth ligand around the metal center. Complex 4 contains an adenine molecule deprotonated and platinated at N1,N6,N7, with two cis-L2Pt units bonded to nitrogen atom N1 and to nitrogen atoms N6 and N7, respectively. With increasing relative concentration of the nucleobase, both complexes 3 and 4 progressively convert into the bis(adduct) 2, the only species detectable in solution when the Ad/Pt molar ratio is 2:1. The trinuclear compound cis-[L2Pt{9-MeAd(-H)}](3)(NO3)(3) (5).
2003
1
128
137
Coordination modes of 9-methyladenine in cis-platinum(II) complexes with dimethyl(phenyl)phosphanes as ancillary ligands - Synthesis and characterization of cis-[PtL2(9-MeAd)(2)](NO3)(2),cis-[PtL2{9-MeAd(-H)}](3)(NO3)(3), and cis-[L2Pt{9-MeAd(-H)}PtL2](NO3)(3) / B., Longato; L., Pasquato; Mucci, Adele; Schenetti, Luisa. - In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. - ISSN 1434-1948. - STAMPA. - 2003:1(2003), pp. 128-137.
B., Longato; L., Pasquato; Mucci, Adele; Schenetti, Luisa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/307024
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