The IPLB-LdFB cell line from the fat body of the insect Lymantria dispar shows the presence of immunoreactive, platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta 1 molecules, as well as the corresponding plasma membrane-like receptors, i.e. PDGFR-alpha, PDGFR-beta and TGFR-beta type II. Cytofluorimetric and morphological studies reveal that the reducing sugar 2-deoxy-D-ribose (dRib), an apoptotic agent for human cells, induces apoptosis in a concentration- and time-dependent manner even in IPLB-LdFB cells. PDGF-AB and TGF-beta 1 partially counteract the effect of dRib, indicating a survival role of these factors in this apoptotic model of insect cells. (C) 1999 Elsevier Science Ltd. All rights reserved.
PDGF and TGF-beta partially prevent 2-deoxy-D-ribose-induced apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar / OTTAVIANI, Enzo; D., Barbieri; FRANCHINI, Antonella; D., Kletsas. - In: JOURNAL OF INSECT PHYSIOLOGY. - ISSN 0022-1910. - STAMPA. - 46:1(2000), pp. 81-87. [10.1016/S0022-1910(99)00104-3]
PDGF and TGF-beta partially prevent 2-deoxy-D-ribose-induced apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar
OTTAVIANI, Enzo;FRANCHINI, Antonella;
2000
Abstract
The IPLB-LdFB cell line from the fat body of the insect Lymantria dispar shows the presence of immunoreactive, platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta 1 molecules, as well as the corresponding plasma membrane-like receptors, i.e. PDGFR-alpha, PDGFR-beta and TGFR-beta type II. Cytofluorimetric and morphological studies reveal that the reducing sugar 2-deoxy-D-ribose (dRib), an apoptotic agent for human cells, induces apoptosis in a concentration- and time-dependent manner even in IPLB-LdFB cells. PDGF-AB and TGF-beta 1 partially counteract the effect of dRib, indicating a survival role of these factors in this apoptotic model of insect cells. (C) 1999 Elsevier Science Ltd. All rights reserved.
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