In 8 patients with symptomatic, acute primary infection with human immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4(+) lymphocytes was seen, accompanied by a marked increase in activated/memory CD8(+) T cells (CD38(+), CD45R0(+), HLA-DR(+), with high amounts of cell adhesion molecules), which represented most circulating lymphocytes, but no gross alterations in vp T cell repertoire. Extremely high plasma levels of proinflammatory cytokines were observed. Three patients were followed for 2-3 years: The number of CD4(+) cells, extremely low at first, increased significantly in a few months but decreased rapidly after a short stable period. Cytotoxic T lymphocytes bearing markers of immunologic activation/memory could play an important role in the earliest phases of the disease. It remains to be established how such a dramatic onset could determine the rapid progression of the infection that seems characteristic of patients with acute HIV syndrome.
Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome / Cossarizza, Andrea; C., Ortolani; Mussini, Cristina; V., Borghi; Guaraldi, Giovanni; N., Mongiardo; E., Bellesia; Mg, Franceschini; B., Derienzo; C., Franceschi. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 172 (1):(1995), pp. 105-112. [10.1093/infdis/172.1.105]
Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome
COSSARIZZA, Andrea;MUSSINI, Cristina;GUARALDI, Giovanni;
1995-01-01
Abstract
In 8 patients with symptomatic, acute primary infection with human immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4(+) lymphocytes was seen, accompanied by a marked increase in activated/memory CD8(+) T cells (CD38(+), CD45R0(+), HLA-DR(+), with high amounts of cell adhesion molecules), which represented most circulating lymphocytes, but no gross alterations in vp T cell repertoire. Extremely high plasma levels of proinflammatory cytokines were observed. Three patients were followed for 2-3 years: The number of CD4(+) cells, extremely low at first, increased significantly in a few months but decreased rapidly after a short stable period. Cytotoxic T lymphocytes bearing markers of immunologic activation/memory could play an important role in the earliest phases of the disease. It remains to be established how such a dramatic onset could determine the rapid progression of the infection that seems characteristic of patients with acute HIV syndrome.Pubblicazioni consigliate
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