Subcutaneous injection of a dilute formaldehyde solution (5 or 10%) into a hind paw induced, in the majority of rats, the appearance of 'mirror pain': licking the contralateral untreated hind paw 10-60 min after injection. Contralateral licking activity was much less frequent than the ipsilaterally directed one, but the overall intensities of the two responses were positively correlated. Qualitatively, the two behaviours were similar. Functional activity levels of the lumbar spinal cord, as revealed by the 2-deoxyglucose (2-DG) technique, were increased bilaterally over the first hour after unilateral hind limb formalin injection in unanesthetized, freely moving rats. The enhancement of the [C-14]2-DG uptake could be detected both in dorsal and ventral horns, as well as in the gray matter surrounding the central canal, and the anterolateral and dorsolateral funiculi. These metabolic changes may reflect an enhancement of the functional activity of both interneuronal pools and units projecting to supraspinal centers, giving rise to a referred contralateral pain.

'Mirror pain' in the formalin test: behavioral and 2-deoxyglucose studies / A. M., Aloisi; Porro, Carlo Adolfo; Cavazzuti, Milena; Baraldi, Patrizia; G., Carli. - In: PAIN. - ISSN 0304-3959. - STAMPA. - 55:(1993), pp. 267-273. [10.1016/0304-3959(93)90156-J]

'Mirror pain' in the formalin test: behavioral and 2-deoxyglucose studies

PORRO, Carlo Adolfo;CAVAZZUTI, Milena;BARALDI, Patrizia;
1993

Abstract

Subcutaneous injection of a dilute formaldehyde solution (5 or 10%) into a hind paw induced, in the majority of rats, the appearance of 'mirror pain': licking the contralateral untreated hind paw 10-60 min after injection. Contralateral licking activity was much less frequent than the ipsilaterally directed one, but the overall intensities of the two responses were positively correlated. Qualitatively, the two behaviours were similar. Functional activity levels of the lumbar spinal cord, as revealed by the 2-deoxyglucose (2-DG) technique, were increased bilaterally over the first hour after unilateral hind limb formalin injection in unanesthetized, freely moving rats. The enhancement of the [C-14]2-DG uptake could be detected both in dorsal and ventral horns, as well as in the gray matter surrounding the central canal, and the anterolateral and dorsolateral funiculi. These metabolic changes may reflect an enhancement of the functional activity of both interneuronal pools and units projecting to supraspinal centers, giving rise to a referred contralateral pain.
1993
55
267
273
'Mirror pain' in the formalin test: behavioral and 2-deoxyglucose studies / A. M., Aloisi; Porro, Carlo Adolfo; Cavazzuti, Milena; Baraldi, Patrizia; G., Carli. - In: PAIN. - ISSN 0304-3959. - STAMPA. - 55:(1993), pp. 267-273. [10.1016/0304-3959(93)90156-J]
A. M., Aloisi; Porro, Carlo Adolfo; Cavazzuti, Milena; Baraldi, Patrizia; G., Carli
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/306742
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 82
  • ???jsp.display-item.citation.isi??? 72
social impact