Objective: We aimed to determine whether second-trimester abortion using isosorbide mononitrate (IMN) in addition to gemeprost is more effective and reduces side effects compared with gerneprost alone. Study design: Eighty women who were age 13 to 23 weeks´ gestation were randomly assigned to receive per vaginam either IMN 40 mg (group 1, 40 women) or placebo (group 2, 40 women) in addition to Gemeprost I mg up to 3 times daily 3 hours apart for 2 days. Analysis of variance, a chi 2 test, and a multivariate analysis were performed. Results: Of the 72 women analyzed, 68% (group 1) and 38% (group 2) underwent abortion within day 1 (P < .05). However, group 1 was associated with more headache (18% of women) 3 hours after induction compared to group 2 (0% of women, P = .038). Conclusion: IMN in addition to gemeprost is effective for second-trimester abortion, but is associated with more headache compared with gemeprost alone.

Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: A double-blind randomized, placebo-controlled multicenter trial / W., Eppel; Facchinetti, Fabio; E., Schleussner; F., Piccinini; C., Pizzi; Dm, Gruber; B., Schneider; W., Tschugguel. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 192:(2005), pp. 856-861.

Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: A double-blind randomized, placebo-controlled multicenter trial

FACCHINETTI, Fabio;
2005

Abstract

Objective: We aimed to determine whether second-trimester abortion using isosorbide mononitrate (IMN) in addition to gemeprost is more effective and reduces side effects compared with gerneprost alone. Study design: Eighty women who were age 13 to 23 weeks´ gestation were randomly assigned to receive per vaginam either IMN 40 mg (group 1, 40 women) or placebo (group 2, 40 women) in addition to Gemeprost I mg up to 3 times daily 3 hours apart for 2 days. Analysis of variance, a chi 2 test, and a multivariate analysis were performed. Results: Of the 72 women analyzed, 68% (group 1) and 38% (group 2) underwent abortion within day 1 (P < .05). However, group 1 was associated with more headache (18% of women) 3 hours after induction compared to group 2 (0% of women, P = .038). Conclusion: IMN in addition to gemeprost is effective for second-trimester abortion, but is associated with more headache compared with gemeprost alone.
192
856
861
Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: A double-blind randomized, placebo-controlled multicenter trial / W., Eppel; Facchinetti, Fabio; E., Schleussner; F., Piccinini; C., Pizzi; Dm, Gruber; B., Schneider; W., Tschugguel. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 192:(2005), pp. 856-861.
W., Eppel; Facchinetti, Fabio; E., Schleussner; F., Piccinini; C., Pizzi; Dm, Gruber; B., Schneider; W., Tschugguel
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/306671
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